Sfoglia per Autore
Recent developments in the field of non peptidic alpha-v beta3 antagonists
2009-01-01 Cacciari, B; Crepaldi, P; Federico, Stephanie; Spalluto, Giampiero
Combining selectivity and affinity predictions using an integrated support vector machine (SVM) approach: A novel tool to discriminate between the human A2A and A3 receptor bonding sites
2009-01-01 Michielan, L; Bolcato, C; Federico, Stephanie; Cacciari B., Bacilieri M; Klotz, Kn; Pastorin, G; Sperduti, A; Spalluto, Giampiero; Moro, S.
Human A3 adenosine receptor as versatile G protein coupled receptor example to validate the receptor homology modeling technology.
2009-01-01 Morizzo, E.; Federico, Stephanie; Spalluto, Giampiero; Moro, S.
Exploring potency and selectivity receptor antagonist profiles using a multilabe classification approach: the human adenosine receptor as a key study
2009-01-01 Michielan, L.; Federico, Stephanie; Terfloth, L.; Hristozov, D.; Cacciari, B.; Klotz, K. N.; Spalluto, Giampiero; Gasteiger, J.; Moro, S.
Receptor Driven Identifications of Novel Human A3 adenosine receptor antagonists as Potential therapeutic agents.
2010-01-01 Paoletta, S; Federico, Stephanie; Spalluto, Giampiero; Moro, S.
Synthesis and pharmacological characyerization of a new series of 5,7-disubstituted [1,2,4]triazolo[1,5-a] [1,3,5]triazine derivatives as adenosine receptor antagonists: a preliminary inspection of ligand receptor recognition process.
2010-01-01 Pastorin, G.; Federico, Stephanie; Paoletta, S.; Corradino, M.; Cateni, Francesca; Cacciari, B.; Klotz, K. N.; Gao, Z. G.; Jacobson, K. A.; Spalluto, Giampiero; Moro, S.
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptor antagonists: new insights into structure affinity relathionship and receptor antagonist recognition.
2010-01-01 Cheong, S. L.; Dolzhenko, A.; Kachler, S.; Paoletta, S.; Federico, Stephanie; Cacciari, B.; Dolzhenko, A.; Klotz, K. N.; Moro, S.; Spalluto, Giampiero; Pastorin, G.
1,2,4-Triazolo[1,5-a]-1,3,5-triazine nucleus: a possible template for adenosine receptor subtypes.
2011-01-01 Federico, Stephanie; Paoletta, Silvia; Cheong, Siew Lee; Pastorin, Giorgia; Cacciari, Barbara; Stragliotto, Stefano; Klotz, Karl Norbert; Siegel, Jeffrey; Gao, Zhan Guo; Jacobson, Kenneth A.; Moro, Stefano; Spalluto, Giampiero
Pyrazolo derivatives as potent adenosine receptor antagonists: An overview on the structure-activity relationships
2011-01-01 Cheong, S. L.; Venkatesan, G.; Paira, P.; Jothibasu, R.; Mandel, A. L.; Federico, Stephanie; Spalluto, Giampiero; Pastorin, G.
5-Alkylamino-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines. Influence of the Substituent on the Affinity at the Adenosine Receptor Subtypes
2011-01-01 Federico, Stephanie; Paoletta, Silvia; Cheong, Siew Lee; Cacciari, Barbara; Klotz, Karl Norbert; Pastorin, Giorgia; Moro, Stefano; Spalluto, Giampiero
Structural investigations on a novel class of 1,2,4-triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
2011-01-01 Federico, Stephanie; Paoletta, Silvia; Cheong, Siew Lee; Pastorin, Giorgia; Cacciari, Barbara; Klotz, Karl Norbert; Moro, Stefano; Spalluto, Giampiero
Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A(3) adenosine receptor antagonists
2011-01-01 Cheong, S. L.; Federico, Stephanie; Venkatesan, G.; Paira, P.; Shao, Y. M.; Spalluto, Giampiero; Yap, C. W.; Pastorin, G.
Synthesis and biological evaluation of a new series of 1,2,4-Triazolo(1,5-a)-1,3,5-triazines as human A2A adenosine receptor antagonists with improved water solubility
2011-01-01 Federico, Stephanie; Paoletta, S.; Cheong, S. L.; Pastorin, G.; Cacciari, B.; Stragliotto, S.; Klotz, K. N.; Siegel, J.; Gao, Z. G.; Jacobson, K. A.; Moro, S.; Spalluto, Giampiero
Does the combination of optimal substitutions at the C(2)-, N(5)- and N(8)-positions of the pyrazolo-triazolo-pyrimidine scaffold guaranteee selective modulation of the human A(3) adenosine receptors?
2011-01-01 Cheong, S. L.; Dolzhenko, A. V.; Paoletta, S.; Lee, E. P. R.; Kachler, S.; Federico, Stephanie; Klotz, K. N.; Dolzhenko, A. V.; Spalluto, Giampiero; Moro, S.; Pastorin, G.
BIOMEDICAL APPLICATIONS I: DELIVERY OF DRUGS
2011-01-01 Spalluto, Giampiero; Federico, Stephanie; Cacciari, Barbara; Bianco, Alberto; Cheong, Siew Lee; Prato, Maurizio
New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A1 adenosine receptor antagonists.
2011-01-01 Catia, Lambertucci; Michela, Buccioni; Barbara, Cacciari; Diego Dal, Ben; Federico, Stephanie; Karl Norbert, Klotz; Gabriella, Marucci; Rosaria, Volpini; Spalluto, Giampiero; Gloria, Cristalli
Exploring Directionality of 5-Substitutions in a New Series of 5-Alkyamino-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a Strategy to Design Novel Human A3 Adenosine Receptors Antagonists.
2012-01-01 Federico, Stephanie; Ciancetta, Antonella; Paoletta, Silvia; Pastorin, Giorgia; Cacciari, Barbara; Klotz, Karl Norbert; Moro, Stefano; Spalluto, Giampiero
Structural Investigations on a Novel Class of [1,2,4]Triazolo[1,5-c]pyrimidines as Adenosine Receptor Antagonists.
2012-01-01 Federico, Stephanie; Paoletta, Silvia; Cacciari, Barbara; Klotz, Karl Norbert; Moro, Stefano; Spalluto, Giampiero
Simplification of Pyrazolo-triazolo-pyrimidine Nucleus for Searching New Adenosine Receptor Antagonists.
2012-01-01 Spalluto, Giampiero; Federico, Stephanie; Pastorin, Giorgia; Paoletta, Silvia; Cacciari, Barbara; Klotz, Karl Norbert; Moro, Stefano
Fluorescent ligands for the A3 adenosine receptor.
2012-01-01 Federico, Stephanie; Paoletta, Silvia; Kozma, Eszter; Kumar, T. Santhosh; Phan, Khai; Gao, Zhan Guo; Jacobson, Kenneth A.; Moro, Stefano; Spalluto, Giampiero
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