Saulsbury et al emphasize the diagnostic challenge of periodic fevers in pediatrics by describing a case of PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and Cervical Adenopathy) that was eventually diagnosed as TNFa Receptor-Associated Period Fever (TRAPS). PFAPA is a syndrome and not a specific disease and—as pointed out previously—some symptoms, for instance aphthous stomatitis, may not be present. Moreover, other symptoms are very common, for example abdominal pain, which is present in 60% of all cases. The importance of these symptoms warrants in many children the evaluation of different diagnoses, including other periodic fevers (hyper-IgD syndrome [HIDS], TRAPS) and even Crohn’s disease. We recently described three cases of HIDS in which the disease onset was characterized by a PFAPA-like symptomatology and by severe abdominal complaints.
CARD15/NOD2 mutations are not related to abdominal PFAPA.
A. TommasiniConceptualization
2006-01-01
Abstract
Saulsbury et al emphasize the diagnostic challenge of periodic fevers in pediatrics by describing a case of PFAPA (Periodic Fever, Aphthous stomatitis, Pharyngitis, and Cervical Adenopathy) that was eventually diagnosed as TNFa Receptor-Associated Period Fever (TRAPS). PFAPA is a syndrome and not a specific disease and—as pointed out previously—some symptoms, for instance aphthous stomatitis, may not be present. Moreover, other symptoms are very common, for example abdominal pain, which is present in 60% of all cases. The importance of these symptoms warrants in many children the evaluation of different diagnoses, including other periodic fevers (hyper-IgD syndrome [HIDS], TRAPS) and even Crohn’s disease. We recently described three cases of HIDS in which the disease onset was characterized by a PFAPA-like symptomatology and by severe abdominal complaints.Pubblicazioni consigliate
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