Bovine and human serum albumins catalyze the aldol reaction of aromatic aledhyedes and acetone, with saturation kinetics and moderate and opposite enantioselectivity. The reaction occurs at the binding site in domain IIa, and is inhibited by warfarin. Kinetic data are consistent with an enamine mechanism. The activity is conserved in a 103 aminoacid peptide derived from the albumin sequence.
Aldolase Activity of Serum Albumins
BENEDETTI, FABIO;BERTI, FEDERICO;BIDOGGIA, SILVIA
2011-01-01
Abstract
Bovine and human serum albumins catalyze the aldol reaction of aromatic aledhyedes and acetone, with saturation kinetics and moderate and opposite enantioselectivity. The reaction occurs at the binding site in domain IIa, and is inhibited by warfarin. Kinetic data are consistent with an enamine mechanism. The activity is conserved in a 103 aminoacid peptide derived from the albumin sequence.File in questo prodotto:
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