Herein we report on the direct observation of chiral recognition events of adsorbed diphenylalanine by scanning tunneling microscopy (STM). The interaction among individual di-d-phenylalanine (d-Phe-d- Phe) molecules and the discrimination of d-Phe-d-Phe from its enantiomer l-Phe-l-Phe on Cu(110) is followed by STM and rationalized by using first principles and classical molecular dynamics techniques. We find that the stereoselective assembly of adsorbed di-phenylalanine enantiomers into molecule pairs and chains takes place through mutually induced conformational changes, thereby illustrating at the single-molecule level the more than half a century old prediction of Pauling.
Tracking the Chiral Recognition of Adsorbed Dipeptides at theSingle-Molecule Level
DE VITA, ALESSANDRO;
2007-01-01
Abstract
Herein we report on the direct observation of chiral recognition events of adsorbed diphenylalanine by scanning tunneling microscopy (STM). The interaction among individual di-d-phenylalanine (d-Phe-d- Phe) molecules and the discrimination of d-Phe-d-Phe from its enantiomer l-Phe-l-Phe on Cu(110) is followed by STM and rationalized by using first principles and classical molecular dynamics techniques. We find that the stereoselective assembly of adsorbed di-phenylalanine enantiomers into molecule pairs and chains takes place through mutually induced conformational changes, thereby illustrating at the single-molecule level the more than half a century old prediction of Pauling.Pubblicazioni consigliate
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