This book chapter is aimed to provide, with a consistent section concerning the physical and chemical issues, the industrial uses of dichloromethane with particular attention to pharmaceutical, nutraceutical, and food purposes. Solubility data in different substances, were reported and estimated by means of Abraham’s model. Due to its toxicity and possible carcinogenic action, methods to avoid residuals in the treated materials such as pharmaceutical, nutraceutical or food compounds will be discussed. As an example, a literature experimental test on dichloromethane removal from a pharmaceutical drug, by supercritical carbon dioxide, is reported. Moreover, two other literature applications of dichloromethane in pharmaceutical technology field were considered.
Dichloromethane: Physicochemical Properties, Applications and Environmental Effects
DE ZORDI, NICOLA;MONEGHINI, MARIAROSA;CORTESI, ANGELO;KIKIC, IRENEO
2012-01-01
Abstract
This book chapter is aimed to provide, with a consistent section concerning the physical and chemical issues, the industrial uses of dichloromethane with particular attention to pharmaceutical, nutraceutical, and food purposes. Solubility data in different substances, were reported and estimated by means of Abraham’s model. Due to its toxicity and possible carcinogenic action, methods to avoid residuals in the treated materials such as pharmaceutical, nutraceutical or food compounds will be discussed. As an example, a literature experimental test on dichloromethane removal from a pharmaceutical drug, by supercritical carbon dioxide, is reported. Moreover, two other literature applications of dichloromethane in pharmaceutical technology field were considered.Pubblicazioni consigliate
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