Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism. As statins induce the translocation of cytosolic Bax to the mitochondria and allow to permeabilize the mitochondrial outer membrane during apoptosis, further studies will be carried out on the expression of proapoptotic genes, such as Bax or Bcl2. These findings, even if obtained in an SH-SY5Y undifferentiated cell line, surely represent a first step towards the understanding of the neuronal damage caused by inflammation processes in MA.

Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line

MARCUZZI, ANNALISA;TRICARICO, PAOLA MAURA;PISCIANZ, ELISA;CROVELLA, SERGIO
2013-01-01

Abstract

Apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism. As statins induce the translocation of cytosolic Bax to the mitochondria and allow to permeabilize the mitochondrial outer membrane during apoptosis, further studies will be carried out on the expression of proapoptotic genes, such as Bax or Bcl2. These findings, even if obtained in an SH-SY5Y undifferentiated cell line, surely represent a first step towards the understanding of the neuronal damage caused by inflammation processes in MA.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2670542
 Avviso

Registrazione in corso di verifica.
La registrazione di questo prodotto non è ancora stata validata in ArTS.

Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 26
social impact