A series of distorted square planar palladium(II) complexes with dithiocarbamic acids of general formula [Pd(L)2], where L = 4-methylpiperazine-l-carbodithioic acid anion, morpholine-4-carbodithioic acid anion or 4-benzylpiperidine-l-carbodithioic acid anion for complexes 1a, 1b and 1c, respectively, have been synthesized. The complexes were characterized by physicochemical and spectroscopic methods; in addition, the structure of complex 1a was characterized by single crystal X-ray crystallography. The interaction of these palladium complexes with CT-DNA was investigated with the help of absorption and emission spectroscopy. The association constant Kb was deduced from the absorption spectra, while the number of binding sites and the binding constant were calculated from the fluorescence quenching data. The results suggest an intercalative interaction of the complexes with CTDNA.
Palladium(II) complexes of dithiocarbamic acids: synthesis, characterization, crystal structure and DNA binding study
ZANGRANDO, ENNIO;
2011-01-01
Abstract
A series of distorted square planar palladium(II) complexes with dithiocarbamic acids of general formula [Pd(L)2], where L = 4-methylpiperazine-l-carbodithioic acid anion, morpholine-4-carbodithioic acid anion or 4-benzylpiperidine-l-carbodithioic acid anion for complexes 1a, 1b and 1c, respectively, have been synthesized. The complexes were characterized by physicochemical and spectroscopic methods; in addition, the structure of complex 1a was characterized by single crystal X-ray crystallography. The interaction of these palladium complexes with CT-DNA was investigated with the help of absorption and emission spectroscopy. The association constant Kb was deduced from the absorption spectra, while the number of binding sites and the binding constant were calculated from the fluorescence quenching data. The results suggest an intercalative interaction of the complexes with CTDNA.Pubblicazioni consigliate
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