Abstract Recently it was reported that microRNA from the miR-17 ~ 92 family may have a key role in chronic lymphocytic leukemia (CLL). Here, we designed specific oligonucleotides to target endogenous miR-17 (antagomiR17). In-vitro administration of antagomiR17 effectively reduced miR-17 expression and the proliferation of CLL-like MEC-1 cells. When injected in-vivo in tumor generated by the MEC-1 cells in SCID mice, antagomiR17 dramatically reduced tumor growth and significantly increase survival. Altogether, our results provide the rationale for the use of antagomiR17 as a novel potential therapeutic tool in CLL and in other lymphoproliferative disorders where miR-17 has a driver role in tumor progression.

Potential therapeutic role of antagomiR17 for the treatment of chronic lymphocytic leukemia.

DEREANI, SARA;MACOR, PAOLO;D'AGARO, TIZIANA;MEZZAROBA, NELLY;CAPOLLA, SARA;ZUCCHETTO, ANTONELLA;ZORZET, SONIA;BOMBEN, RICCARDO
2014-01-01

Abstract

Abstract Recently it was reported that microRNA from the miR-17 ~ 92 family may have a key role in chronic lymphocytic leukemia (CLL). Here, we designed specific oligonucleotides to target endogenous miR-17 (antagomiR17). In-vitro administration of antagomiR17 effectively reduced miR-17 expression and the proliferation of CLL-like MEC-1 cells. When injected in-vivo in tumor generated by the MEC-1 cells in SCID mice, antagomiR17 dramatically reduced tumor growth and significantly increase survival. Altogether, our results provide the rationale for the use of antagomiR17 as a novel potential therapeutic tool in CLL and in other lymphoproliferative disorders where miR-17 has a driver role in tumor progression.
2014
http://www.jhoonline.org/content/7/1/79
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2859924
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