Purpose: To determine whether magnetic resonance enterography (MRE) performed without intravenous contrast injection is diagnostically noninferior to conventional contrast-enhanced MRE (CE-MRE) in patients with Crohn’s disease (CD). Materials and Methods: This was an Institutional Review Board (IRB)-approved retrospective study. Ninety-six patients (52 male and 44 female; 47.18 years 6 13.6) with a diagnosis of CD underwent MRE at 1.5T including T2-weighted single-shot turbo-spin-echo, T2-weighted spectral fat presaturation with inversion recovery (SPAIR), T1-weighted balanced fast-field-echo MR sequences, and CE-MRE consisting in T1-weighted breath-hold THRIVE 3D MRI sequences after administration of gadobenate dimeglumine (0.2 mL/kg of body weight). Unenhanced MRE, CE-MRE, and unenhanced MRE plus CE-MRE were reviewed in separate sessions with blinding by two readers in consensus, and subsequently by two other readers independently considering a subgroup of 20 patients. Crohn’s Disease Endoscopic Index of Severity (CDEIS) and/or histologic analysis of the surgical specimen were considered as reference standards for the assessment of inflammatory activity. Results: Patients revealed prevalently active (n 5 55 patients) or quiescent CD (n 5 41 patients). The agreement between unenhanced MRE vs. CE-MRE in interpreting active bowel inflammation was 96% (123/128 bowel segments; one-sided 95% confidence interval [CI], >94.4%). Unenhanced MRE vs. CE-MRE vs. unenhanced MRE plus CE-MRE revealed a diagnostic accuracy of 93% [90/96] vs. 92% [88/96] vs. 97% [93/96] (P > 0.05) in the diagnosis of active CD. Interreader agreement was very good for all variables (j value 5 0.8–0.9) except for the measurement of the length of disease (j value 5 0.45). Conclusion: Unenhanced MRE was noninferior to CE-MRE in diagnosing active inflammation in patients with CD.

Impact of gadolinium-based contrast agent in the assessment of Crohn's disease activity: Is contrast agent injection necessary?

QUAIA, Emilio;SOZZI, MICHELE;GENNARI, ANTONIO GIULIO;PONTELLO, MICHELE;ANGILERI, ROBERTA;COVA, MARIA ASSUNTA
2016-01-01

Abstract

Purpose: To determine whether magnetic resonance enterography (MRE) performed without intravenous contrast injection is diagnostically noninferior to conventional contrast-enhanced MRE (CE-MRE) in patients with Crohn’s disease (CD). Materials and Methods: This was an Institutional Review Board (IRB)-approved retrospective study. Ninety-six patients (52 male and 44 female; 47.18 years 6 13.6) with a diagnosis of CD underwent MRE at 1.5T including T2-weighted single-shot turbo-spin-echo, T2-weighted spectral fat presaturation with inversion recovery (SPAIR), T1-weighted balanced fast-field-echo MR sequences, and CE-MRE consisting in T1-weighted breath-hold THRIVE 3D MRI sequences after administration of gadobenate dimeglumine (0.2 mL/kg of body weight). Unenhanced MRE, CE-MRE, and unenhanced MRE plus CE-MRE were reviewed in separate sessions with blinding by two readers in consensus, and subsequently by two other readers independently considering a subgroup of 20 patients. Crohn’s Disease Endoscopic Index of Severity (CDEIS) and/or histologic analysis of the surgical specimen were considered as reference standards for the assessment of inflammatory activity. Results: Patients revealed prevalently active (n 5 55 patients) or quiescent CD (n 5 41 patients). The agreement between unenhanced MRE vs. CE-MRE in interpreting active bowel inflammation was 96% (123/128 bowel segments; one-sided 95% confidence interval [CI], >94.4%). Unenhanced MRE vs. CE-MRE vs. unenhanced MRE plus CE-MRE revealed a diagnostic accuracy of 93% [90/96] vs. 92% [88/96] vs. 97% [93/96] (P > 0.05) in the diagnosis of active CD. Interreader agreement was very good for all variables (j value 5 0.8–0.9) except for the measurement of the length of disease (j value 5 0.45). Conclusion: Unenhanced MRE was noninferior to CE-MRE in diagnosing active inflammation in patients with CD.
2016
Pubblicato
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jmri.25024/abstract
File in questo prodotto:
File Dimensione Formato  
jmri25024.pdf

Accesso chiuso

Tipologia: Documento in Versione Editoriale
Licenza: Digital Rights Management non definito
Dimensione 374.11 kB
Formato Adobe PDF
374.11 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
2867306_jmri25024-PostPrint.pdf

Open Access dal 07/08/2016

Descrizione: Post Print VQR3 - This is the peer reviewed version of the following article: Quaia E., Sozzi M., Gennari A.G., Pontello M., Angileri R., Cova M.A. Impact of gadolinium-based contrast agent in the assessment of Crohn's disease activity: Is contrast agent injection necessary?. J Magn Reson Imaging. 2016 Mar;43(3):688-97 which has been published in final form at https://doi.org/10.1002/jmri.25024. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Tipologia: Bozza finale post-referaggio (post-print)
Licenza: Digital Rights Management non definito
Dimensione 963.06 kB
Formato Adobe PDF
963.06 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2867306
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 12
social impact