Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. Objetive and Method: We evaluated the distribution of selected SNPs in APOBEC3G (rs3736685, rs2294367) and CUL5 (rs7117111, rs7103534, rs11212495) genes, among 264 HIV-1 infected (HIV-1+) and 259 unexposed uninfected individuals from Northeast Brazil, looking for a possible association with susceptibility to HIV-1 infection, viral load, CD4+ T cell count and success of antiretroviral therapy.

CUL5 and APOBEC3G polymorphisms are partially implicated in HIV-1 infection and antiretroviral therapy in a Brazilian population

Crovella, Sérgio
2017-01-01

Abstract

Host restriction factors are cellular proteins able to diminish or block viral replication in a cell-specific way. Objetive and Method: We evaluated the distribution of selected SNPs in APOBEC3G (rs3736685, rs2294367) and CUL5 (rs7117111, rs7103534, rs11212495) genes, among 264 HIV-1 infected (HIV-1+) and 259 unexposed uninfected individuals from Northeast Brazil, looking for a possible association with susceptibility to HIV-1 infection, viral load, CD4+ T cell count and success of antiretroviral therapy.
2017
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http://www.eurekaselect.com/150886/article
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2921399
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