What was the TRUFFLE study? The Trial of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE) was a prospective, multicenter, unblinded, randomized trial that ran between 1 January 2005 and 1 October 2010 in 20 European centers 1 . It studied singleton pregnancies at 26–32 weeks of gestation with a diagnosis of fetal growth restriction (FGR), defined as abdominal circumference < 10th percentile and high umbilical artery Doppler pulsatility index (PI) (> 95th percentile). In order to assess whether changes in the fetal ductus venosus (DV) Doppler waveform or short-term variation (STV) on cardiotocography (CTG) should be used as a trigger for delivery in these pregnancies, the 503 included women were randomly allocated to one of three ‘timing-of-delivery’ plans (with 1 : 1 : 1 randomization).

Severe fetal growth restriction at 26–32 weeks : key messages from the TRUFFLE study

Ferrazzi, E.;Stampalija, T.;
2017-01-01

Abstract

What was the TRUFFLE study? The Trial of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE) was a prospective, multicenter, unblinded, randomized trial that ran between 1 January 2005 and 1 October 2010 in 20 European centers 1 . It studied singleton pregnancies at 26–32 weeks of gestation with a diagnosis of fetal growth restriction (FGR), defined as abdominal circumference < 10th percentile and high umbilical artery Doppler pulsatility index (PI) (> 95th percentile). In order to assess whether changes in the fetal ductus venosus (DV) Doppler waveform or short-term variation (STV) on cardiotocography (CTG) should be used as a trigger for delivery in these pregnancies, the 503 included women were randomly allocated to one of three ‘timing-of-delivery’ plans (with 1 : 1 : 1 randomization).
2017
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https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.18815
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2955278
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