%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Federico Marchetti, Maurizio Bonati, Alessandra Maestro, Davide Zanon, Francesca Rovere, Alberto Arrighini, Egidio Barbi, Paolo Bertolani, Paolo Biban, Liviana Da Dalt, Andrea Guala, Elisa Mazzoni, Anna Pazzaglia, Paolo Francesco Perri, Antonino Reale, Salvatore Renna, Antonio Francesco Urbino, Enrico Valletta, Antonio Vitale, Tiziana Zangardi, Antonio Clavenna, Luca Ronfani, on behalf of the SONDO (Study ONdansetron vs DOmperidone) Investigators
Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref010)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref012)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref013)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref014)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref015)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref019)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref018)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref004)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref020)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref004)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref015)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref017)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref018)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0165441.ref023)>>
endobj
13 0 obj
[38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R]
endobj
38 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 526.2296 m
199.9998 526.2296 l
199.9998 526.7296 l
575.9997 526.7296 l
f*
0.83 0.64 0.02 0 k
314.3622 407.1685 m
319.1244 407.1685 l
h
f*
321.3354 407.1685 m
326.0976 407.1685 l
h
f*
529.7953 394.1291 m
534.5575 394.1291 l
h
f*
474.9165 368.1638 m
479.6787 368.1638 l
h
f*
203.4142 342.1417 m
208.1764 342.1417 l
h
f*
485.0079 303.137 m
489.7701 303.137 l
h
f*
494.9291 303.137 m
499.6913 303.137 l
h
f*
331.1433 277.1717 m
335.8488 277.1717 l
h
f*
340.3276 277.1717 m
345.0898 277.1717 l
h
f*
329.6693 238.1669 m
339.1937 238.1669 l
h
f*
343.6157 238.1669 m
353.1402 238.1669 l
h
f*
203.4142 212.1449 m
212.9386 212.1449 l
h
f*
320.9953 199.1622 m
330.5197 199.1622 l
h
f*
334.9984 199.1622 m
344.4661 199.1622 l
h
f*
389.537 173.1402 m
399.0047 173.1402 l
h
f*
404.2205 173.1402 m
413.6882 173.1402 l
h
f*
272.4661 121.1528 m
281.9906 121.1528 l
h
f*
297.9213 108.1701 m
302.6835 108.1701 l
h
f*
307.1622 108.1701 m
316.6299 108.1701 l
h
f*
526.5638 95.1307 m
531.326 95.1307 l
h
f*
535.8047 95.1307 m
545.2724 95.1307 l
h
f*
549.7512 95.1307 m
559.2756 95.1307 l
h
f*
200.0126 82.148 m
209.537 82.148 l
h
f*
214.6961 82.148 m
224.2205 82.148 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(successful)Tj
4.8397 0 Td
(for)Tj
1.3785 0 Td
(832)Tj
1.862 0 Td
(\(63.4%\);)Tj
3.9625 0 Td
(356)Tj
1.8679 0 Td
(underwent)Tj
4.8338 0 Td
(randomization)Tj
6.4271 0 Td
(\(the)Tj
1.9216 0 Td
(parents)Tj
3.5209 0 Td
(of)Tj
1.0444 0 Td
(125)Tj
1.8678 0 Td
(children)Tj
3.6701 0 Td
(did)Tj
-37.1963 -1.474 Td
(not)Tj
1.5933 0 Td
(give)Tj
2.029 0 Td
(consent\):)Tj
4.2908 0 Td
(118)Tj
1.8678 0 Td
(to)Tj
1.0444 0 Td
(placebo,)Tj
3.9565 0 Td
(119)Tj
1.8619 0 Td
(to)Tj
1.0503 0 Td
(domperidone,)Tj
6.2601 0 Td
(and)Tj
1.8679 0 Td
(119)Tj
1.8619 0 Td
(to)Tj
1.0503 0 Td
(ondansetron.)Tj
5.9915 0 Td
(Fourteen)Tj
-34.7257 -1.474 Td
(\(11.8%\))Tj
3.682 0 Td
(needed)Tj
3.5149 0 Td
(intravenous)Tj
5.3292 0 Td
(rehydration)Tj
5.156 0 Td
(in)Tj
0.9847 0 Td
(the)Tj
1.5933 0 Td
(ondansetron)Tj
5.7171 0 Td
(group)Tj
2.7451 0 Td
(vs)Tj
1.2114 0 Td
(30)Tj
1.3189 0 Td
(\(25.2%\))Tj
3.682 0 Td
(and)Tj
1.8679 0 Td
(34)Tj
-36.8025 -1.474 Td
(\(28.8%\))Tj
3.682 0 Td
(in)Tj
0.9847 0 Td
(the)Tj
1.5933 0 Td
(domperido)Tj
4.6727 0 Td
(ne)Tj
1.3129 0 Td
(and)Tj
1.8679 0 Td
(placebo)Tj
3.676 0 Td
(groups,)Tj
3.515 0 Td
(respective)Tj
4.5115 0 Td
(ly.)Tj
1.2055 0 Td
(Ondansetron)Tj
5.9438 0 Td
(reduced)Tj
3.7894 0 Td
(the)Tj
-36.7547 -1.474 Td
(risk)Tj
1.7544 0 Td
(of)Tj
1.0503 0 Td
(intravenous)Tj
5.3232 0 Td
(rehydration)Tj
5.162 0 Td
(by)Tj
1.2652 0 Td
(over)Tj
2.1423 0 Td
(50%,)Tj
2.4766 0 Td
(both)Tj
2.1484 0 Td
(vs)Tj
1.2114 0 Td
(placebo)Tj
3.6761 0 Td
(\(RR)Tj
1.9813 0 Td
(0.41,)Tj
2.4169 0 Td
(98.6%)Tj
3.0315 0 Td
(CI)Tj
1.2115 0 Td
(0.20)Tj
-34.8511 -1.474 Td
(0.83\))Tj
2.4706 0 Td
(and)Tj
1.8678 0 Td
(domperidone)Tj
5.9856 0 Td
(\(RR)Tj
1.9813 0 Td
(0.47,)Tj
2.4169 0 Td
(98.6%)Tj
3.0315 0 Td
(CI)Tj
1.2115 0 Td
(0.230.97\).)Tj
5.2217 0 Td
(No)Tj
1.4859 0 Td
(differences)Tj
5.0546 0 Td
(for)Tj
1.3785 0 Td
(adverse)Tj
3.7358 0 Td
(events)Tj
-35.8417 -1.474 Td
(were)Tj
2.3631 0 Td
(seen)Tj
2.3632 0 Td
(among)Tj
3.2405 0 Td
(groups.)Tj
3.5209 0 Td
(In)Tj
1.0443 0 Td
(a)Tj
0.7699 0 Td
(context)Tj
3.4135 0 Td
(of)Tj
1.0503 0 Td
(emergency)Tj
5.1142 0 Td
(care,)Tj
2.4229 0 Td
(6)Tj
0.7698 0 Td
(out)Tj
1.5934 0 Td
(of)Tj
1.0443 0 Td
(10)Tj
1.3189 0 Td
(children)Tj
3.6701 0 Td
(aged)Tj
2.4169 0 Td
(16)Tj
-36.1162 -1.474 Td
(years)Tj
2.6377 0 Td
(with)Tj
1.9752 0 Td
(vomiting)Tj
3.9029 0 Td
(due)Tj
1.8679 0 Td
(to)Tj
1.0443 0 Td
(gastroenteritis)Tj
6.4272 0 Td
(and)Tj
1.8679 0 Td
(without)Tj
3.3478 0 Td
(severe)Tj
3.1927 0 Td
(dehydration)Tj
5.3769 0 Td
(can)Tj
1.8141 0 Td
(be)Tj
1.3189 0 Td
(managed)Tj
-34.7735 -1.474 Td
(effectively)Tj
4.6189 0 Td
(with)Tj
1.9753 0 Td
(administration)Tj
6.3675 0 Td
(of)Tj
1.0443 0 Td
(oral)Tj
1.8619 0 Td
(rehydration)Tj
5.1621 0 Td
(solution)Tj
3.6164 0 Td
(alone.)Tj
2.9122 0 Td
(In)Tj
1.0443 0 Td
(children)Tj
3.6701 0 Td
(who)Tj
2.035 0 Td
(fail)Tj
1.474 0 Td
(oral)Tj
-35.782 -1.474 Td
(rehydration,)Tj
5.4365 0 Td
(a)Tj
0.7698 0 Td
(single)Tj
2.7929 0 Td
(oral)Tj
1.8619 0 Td
(dose)Tj
2.3632 0 Td
(of)Tj
1.0443 0 Td
(ondansetron)Tj
5.7111 0 Td
(reduces)Tj
3.7417 0 Td
(the)Tj
1.5933 0 Td
(need)Tj
2.4169 0 Td
(for)Tj
1.3726 0 Td
(intravenous)Tj
5.3291 0 Td
(rehydration)Tj
-34.4333 -1.4741 Td
(and)Tj
1.8619 0 Td
(the)Tj
1.5993 0 Td
(percentage)Tj
5.162 0 Td
(of)Tj
1.0503 0 Td
(children)Tj
3.6701 0 Td
(who)Tj
2.029 0 Td
(continue)Tj
3.9566 0 Td
(to)Tj
1.0443 0 Td
(vomit,)Tj
2.8645 0 Td
(thereby)Tj
3.5209 0 Td
(facilitating)Tj
4.6011 0 Td
(the)Tj
1.5933 0 Td
(success)Tj
3.8014 0 Td
(of)Tj
1.0444 0 Td
(oral)Tj
-37.7991 -1.474 Td
(rehydration.)Tj
5.4365 0 Td
(Domperidone)Tj
6.1526 0 Td
(was)Tj
1.9813 0 Td
(not)Tj
1.5934 0 Td
(effective)Tj
3.9088 0 Td
(for)Tj
1.3725 0 Td
(the)Tj
1.5934 0 Td
(symptoma)Tj
4.5832 0 Td
(tic)Tj
1.2054 0 Td
(treatment)Tj
4.4101 0 Td
(of)Tj
1.0444 0 Td
(vomiting)Tj
3.9028 0 Td
(dur-)Tj
-37.1844 -1.474 Td
(ing)Tj
1.5336 0 Td
(acute)Tj
2.6377 0 Td
(gastroenteritis.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 451.2188 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 434.211 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Acute)Tj
2.5738 0 Td
(gastroenteritis)Tj
5.9187 0 Td
(\(AGE\))Tj
2.8686 0 Td
(is)Tj
0.8448 0 Td
(the)Tj
1.474 0 Td
(main)Tj
2.2903 0 Td
(cause)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(acute)Tj
2.3244 0 Td
(vomiting)Tj
3.8494 0 Td
(in)Tj
1.0375 0 Td
(children)Tj
3.5546 0 Td
(under)Tj
2.6192 0 Td
(the)Tj
1.4683 0 Td
(age)Tj
1.5421 0 Td
(of)Tj
1.0148 0 Td
(3)Tj
-36.7821 -1.2982 Td
(years)Tj
2.262 0 Td
(and)Tj
1.7291 0 Td
(one)Tj
1.7008 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(important)Tj
4.2859 0 Td
(reasons)Tj
3.2258 0 Td
(for)Tj
1.3833 0 Td
(admission)Tj
4.3143 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(pediatric)Tj
3.7474 0 Td
(emergency)Tj
4.5751 0 Td
(depart-)Tj
-34.4067 -1.2983 Td
(ment)Tj
2.3073 0 Td
(\(ED\))Tj
2.2054 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(hospital)Tj
3.3789 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
2.3017 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(USA,)Tj
2.3414 0 Td
(1.5)Tj
1.3947 0 Td
(million)Tj
3.1237 0 Td
(children)Tj
3.5546 0 Td
(under)Tj
2.6192 0 Td
(5)Tj
0.6917 0 Td
(years)Tj
2.2677 0 Td
(are)Tj
1.4456 0 Td
(diagnosed)Tj
-33.4145 -1.3039 Td
(with)Tj
1.9955 0 Td
(AGE)Tj
2.1884 0 Td
(annually)Tj
3.6623 0 Td
(and)Tj
1.7291 0 Td
(this)Tj
1.6725 0 Td
(condition)Tj
4.1158 0 Td
(accounts)Tj
3.7417 0 Td
(for)Tj
1.389 0 Td
(13%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1451 0 Td
(hospital)Tj
3.3789 0 Td
(admissions)Tj
4.6772 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(The)Tj
-34.2366 -1.2983 Td
(most)Tj
2.2053 0 Td
(frequent)Tj
3.6056 0 Td
(complication)Tj
5.4822 0 Td
(is)Tj
0.8447 0 Td
(dehydration.)Tj
5.3348 0 Td
(In)Tj
1.1112 0 Td
(Europe,)Tj
3.3618 0 Td
(at)Tj
0.9525 0 Td
(least)Tj
1.9785 0 Td
(230)Tj
1.6498 0 Td
(deaths)Tj
2.7893 0 Td
(and)Tj
1.7348 0 Td
(over)Tj
1.9729 0 Td
(87,000)Tj
2.8233 0 Td
(hos-)Tj
-35.8467 -1.2982 Td
(pitalizations)Tj
5.0796 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
3.5546 0 Td
(under)Tj
2.6192 0 Td
(5)Tj
0.6973 0 Td
(years)Tj
2.2621 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.542 0 Td
(are)Tj
1.4513 0 Td
(reported)Tj
3.6567 0 Td
(every)Tj
2.3471 0 Td
(year.[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
-24.0433 -1.3039 Td
(In)Tj
1.1111 0 Td
(the)Tj
1.4684 0 Td
(initial)Tj
2.5511 0 Td
(phase)Tj
2.4832 0 Td
(of)Tj
1.0148 0 Td
(AGE,)Tj
2.4151 0 Td
(vomiting)Tj
3.8437 0 Td
(is)Tj
0.8504 0 Td
(reported)Tj
3.6624 0 Td
(in)Tj
1.0318 0 Td
(75%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
3.5603 0 Td
(with)Tj
1.9956 0 Td
(rotavirus)Tj
3.8097 0 Td
(infection)Tj
-33.9361 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(],)Tj
1.5987 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
0.8504 0 Td
(distressing)Tj
4.473 0 Td
(for)Tj
1.3833 0 Td
(both)Tj
2.0636 0 Td
(patients)Tj
3.3676 0 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.109 0 Td
(families.)Tj
3.5489 0 Td
(Vomiting)Tj
4.0876 0 Td
(is)Tj
0.8503 0 Td
(a)Tj
0.652 0 Td
(direct)Tj
2.5342 0 Td
(cause)Tj
2.3867 0 Td
(of)Tj
1.0148 0 Td
(fluid)Tj
-34.3783 -1.2983 Td
(loss)Tj
1.6951 0 Td
(and)Tj
1.7291 0 Td
(can)Tj
1.6271 0 Td
(also)Tj
1.7688 0 Td
(hamper)Tj
3.3108 0 Td
(successful)Tj
4.1612 0 Td
(treatment)Tj
4.1386 0 Td
(with)Tj
1.9956 0 Td
(oral)Tj
1.7801 0 Td
(rehydration)Tj
4.9493 0 Td
(solution)Tj
3.4866 0 Td
(\(ORS\).)Tj
2.965 0 Td
(Symp-)Tj
-33.6073 -1.2982 Td
(tomatic)Tj
3.2654 0 Td
(pharmacological)Tj
6.8428 0 Td
(treatment)Tj
4.1386 0 Td
(for)Tj
1.3833 0 Td
(vomiting)Tj
3.8494 0 Td
(is)Tj
0.8504 0 Td
(still)Tj
1.6384 0 Td
(a)Tj
0.652 0 Td
(matter)Tj
2.863 0 Td
(of)Tj
1.0148 0 Td
(debate)Tj
2.8346 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
0.8504 0 Td
(not)Tj
1.576 0 Td
(systemati-)Tj
-33.4882 -1.304 Td
(cally)Tj
2.0239 0 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(current)Tj
3.1862 0 Td
(practice)Tj
3.3788 0 Td
(recommendations)Tj
7.5005 0 Td
(for)Tj
1.3889 0 Td
(pediatric)Tj
3.7474 0 Td
(AGE)Tj
2.1883 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
2.5966 0 Td
(Physicians)Tj
4.422 0 Td
(and)Tj
-35.1777 -1.2982 Td
(parents)Tj
3.1747 0 Td
(in)Tj
1.0318 0 Td
(ED)Tj
1.5251 0 Td
(favor)Tj
2.279 0 Td
(intravenous)Tj
4.9606 0 Td
(fluid)Tj
2.075 0 Td
(therapy)Tj
3.2484 0 Td
(\(IVT\))Tj
2.5455 0 Td
(for)Tj
1.389 0 Td
(mild)Tj
2.0806 0 Td
(or)Tj
1.0942 0 Td
(moderate)Tj
4.0252 0 Td
(dehydration)Tj
5.108 0 Td
(when)Tj
-34.5371 -1.2983 Td
(vomiting)Tj
3.8437 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(major)Tj
2.6079 0 Td
(symptom)Tj
4.0025 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(9)Tj
0 g
(].)Tj
1.2585 0 Td
(Thus,)Tj
2.4775 0 Td
(effective)Tj
3.5093 0 Td
(antiemetic)Tj
4.422 0 Td
(treatment)Tj
4.1385 0 Td
(would)Tj
2.7099 0 Td
(lead)Tj
1.8539 0 Td
(to)Tj
1.0205 0 Td
(an)Tj
-35.4215 -1.3039 Td
(important)Tj
4.2802 0 Td
(reduction)Tj
4.1159 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(IVT.)Tj
-12.2512 -1.2983 Td
(Various)Tj
3.3845 0 Td
(antiemetic)Tj
4.422 0 Td
(agents)Tj
2.7553 0 Td
(are)Tj
1.4456 0 Td
(available)Tj
3.6681 0 Td
(and)Tj
1.7291 0 Td
(are)Tj
1.4513 0 Td
(often)Tj
2.2847 0 Td
(used)Tj
2.058 0 Td
(off-label)Tj
3.5092 0 Td
(to)Tj
1.0262 0 Td
(prevent)Tj
3.2598 0 Td
(or)Tj
1.0941 0 Td
(reduce)Tj
-33.2841 -1.2982 Td
(vomiting)Tj
3.8437 0 Td
(in)Tj
1.0375 0 Td
(children)Tj
3.5546 0 Td
(with)Tj
2.0012 0 Td
(AGE)Tj
2.1884 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(11)Tj
0 g
(].)Tj
1.7348 0 Td
(In)Tj
1.1111 0 Td
(France,)Tj
3.1748 0 Td
(Spain,)Tj
2.6873 0 Td
(Italy)Tj
1.9955 0 Td
(and)Tj
1.7292 0 Td
(in)Tj
1.0374 0 Td
(other)Tj
2.3471 0 Td
(European)Tj
4.1159 0 Td
(coun-)Tj
-34.2933 -1.3039 Td
(tries,)Tj
2.1656 0 Td
(the)Tj
1.4683 0 Td
(dopamine)Tj
4.2633 0 Td
(receptor)Tj
3.5603 0 Td
(antagonist)Tj
4.3824 0 Td
(domperidone)Tj
5.6579 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(preferred)Tj
3.9345 0 Td
(antiemetic)Tj
4.4276 0 Td
(treatment)Tj
-32.1786 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.0749 0 Td
(Ondansetron)Tj
5.5332 0 Td
(is)Tj
0.8504 0 Td
(administered)Tj
5.4878 0 Td
(to)Tj
1.0262 0 Td
(only)Tj
1.9785 0 Td
(a)Tj
0.652 0 Td
(small)Tj
2.3301 0 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
1.0148 0 Td
(children)Tj
3.5547 0 Td
(and)Tj
1.7291 0 Td
(its)Tj
1.1452 0 Td
(use)Tj
1.5363 0 Td
(varies)Tj
2.5285 0 Td
(sig-)Tj
-36.0734 -1.2983 Td
(nificantly)Tj
3.9968 0 Td
(among)Tj
2.9933 0 Td
(institutions)Tj
4.7679 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7404 0 Td
(14)Tj
0 g
(].)Tj
-12.3022 -1.2982 Td
(Literature)Tj
4.1782 0 Td
(evaluating)Tj
4.3143 0 Td
(the)Tj
1.474 0 Td
(efficacy)Tj
3.2202 0 Td
(of)Tj
1.0147 0 Td
(symptomatic)Tj
5.4199 0 Td
(drugs)Tj
2.4718 0 Td
(in)Tj
1.0374 0 Td
(reducing)Tj
3.7758 0 Td
(acute)Tj
2.3243 0 Td
(vomiting)Tj
3.8495 0 Td
(for)Tj
-34.2763 -1.304 Td
(pediatric)Tj
3.7473 0 Td
(AGE)Tj
2.1884 0 Td
(focuses)Tj
3.1124 0 Td
(mainly)Tj
2.9933 0 Td
(on)Tj
1.2756 0 Td
(ondansetron)Tj
5.2951 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
3.5433 0 Td
(Evidence)Tj
3.8608 0 Td
(exists)Tj
2.3924 0 Td
(that)Tj
1.7801 0 Td
(ondansetron)Tj
5.2951 0 Td
(com-)Tj
-35.4838 -1.2982 Td
(pared)Tj
2.4944 0 Td
(with)Tj
1.9956 0 Td
(placebo)Tj
3.2768 0 Td
(increases)Tj
3.8324 0 Td
(the)Tj
1.4741 0 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
1.9955 0 Td
(cessation)Tj
3.8438 0 Td
(of)Tj
1.0148 0 Td
(vomiting,)Tj
4.0762 0 Td
(reduces)Tj
3.2768 0 Td
(the)Tj
-36.2945 -1.2983 Td
(immediate)Tj
4.49 0 Td
(hospital)Tj
3.3732 0 Td
(admission)Tj
4.303 0 Td
(rate)Tj
1.7404 0 Td
(and)Tj
1.7178 0 Td
(the)Tj
1.4627 0 Td
(need)Tj
2.1373 0 Td
(for)Tj
1.3776 0 Td
(IVT.)Tj
2.0806 0 Td
(However,)Tj
4.0706 0 Td
(not)Tj
1.5647 0 Td
(all)Tj
1.1395 0 Td
(of)Tj
1.0035 0 Td
(these)Tj
2.245 0 Td
(studies)Tj
2.982 0 Td
(eval-)Tj
-35.6879 -1.3039 Td
(uate)Tj
1.9048 0 Td
(first-line)Tj
3.6397 0 Td
(oral)Tj
1.7801 0 Td
(rehydration)Tj
4.9493 0 Td
(therapy)Tj
3.2485 0 Td
(\(ORT\))Tj
2.88 0 Td
(during)Tj
2.9253 0 Td
(hospital)Tj
3.3789 0 Td
(stay)Tj
1.7688 0 Td
(before)Tj
2.7382 0 Td
(the)Tj
1.4684 0 Td
(administration)Tj
-30.682 -1.2983 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(antiemetic)Tj
4.422 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
2.0806 0 Td
(and)Tj
1.7291 0 Td
(an)Tj
1.2019 0 Td
(adequate)Tj
3.7928 0 Td
(comparative)Tj
5.1703 0 Td
(evaluation)Tj
4.3653 0 Td
(between)Tj
3.5263 0 Td
(domperidone)Tj
5.6579 0 Td
(and)Tj
-34.4293 -1.2982 Td
(ondansetron)Tj
5.295 0 Td
(is)Tj
0.8448 0 Td
(missing)Tj
3.3108 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(20)Tj
0 g
(].)Tj
1.7348 0 Td
(Concerning)Tj
4.989 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(domperidone,)Tj
5.8847 0 Td
(only)Tj
1.9786 0 Td
(few)Tj
1.6157 0 Td
(studies)Tj
2.9877 0 Td
(are)Tj
1.4457 0 Td
(avail-)Tj
-35.3648 -1.304 Td
(able)Tj
1.8311 0 Td
(with)Tj
1.9956 0 Td
(small)Tj
2.3244 0 Td
(sample)Tj
3.0217 0 Td
(sizes,)Tj
2.2734 0 Td
(low)Tj
1.6554 0 Td
(methodological)Tj
6.4233 0 Td
(quality,)Tj
3.1804 0 Td
(and)Tj
1.7291 0 Td
(inconsistent)Tj
5.074 0 Td
(results)Tj
2.8063 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-34.9736 -1.2982 Td
(18)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 355.4645 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Symptomatic)Tj
5.9173 0 Td
(Treatment)Tj
4.7127 0 Td
(of)Tj
1.0417 0 Td
(Acute)Tj
2.7425 0 Td
(Gastroe)Tj
3.5009 0 Td
(nteritis)Tj
3.111 0 Td
(\(SONDO)Tj
4.1811 0 Td
(RCT\))Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0165)Tj
3.5434 0 Td
(441)Tj
2.6362 0 Td
(November)Tj
4.7622 0 Td
(23,)Tj
1.5874 0 Td
(2016)Tj
36.7515 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(15)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(publication.)Tj
4.4858 0 Td
(The)Tj
1.5945 0 Td
(findings)Tj
3.1748 0 Td
(and)Tj
1.5875 0 Td
(conclusions)Tj
4.6559 0 Td
(in)Tj
0.8858 0 Td
(this)Tj
-16.3843 -1.3748 Td
(report)Tj
2.459 0 Td
(are)Tj
1.3678 0 Td
(those)Tj
2.2677 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(authors)Tj
3.0473 0 Td
(and)Tj
1.5874 0 Td
(do)Tj
1.1693 0 Td
(not)Tj
-14.2158 -1.3749 Td
(necessaril)Tj
3.6921 0 Td
(y)Tj
0.6449 0 Td
(represent)Tj
3.7205 0 Td
(the)Tj
1.3748 0 Td
(official)Tj
2.6221 0 Td
(position)Tj
3.1748 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-16.1788 -1.3748 Td
(Italian)Tj
2.4307 0 Td
(Medicines)Tj
3.9969 0 Td
(Agency.)Tj
/F8 1 Tf
-6.4276 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
BT
10.3394 76.4651 Td
(exist.)Tj
ET
Q
endstream
endobj
59 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 61 0 R/Contents 62 0 R/TrimBox[0 0 612 792]>>
endobj
60 0 obj
<>
endobj
63 0 obj
<>
endobj
66 0 obj
<>stream
MinionPro-Regular 6 )
H? HD H\ ' - 3 > H N T Z ` j q t { +2=CIU[cnz~
"(.9CIOU[elov|&-8>DPV^iuy &+/49@DGLPU[]_ahjmru|
&-4;BIPW^elsz
")07>ELSZahov} %,3:AHOV]dkry#/;JTey ! ( / 6 = D K R Y ` g n u |
$
+
2
9
@
G
N
U
\
c
j
q
x
'.5<CJQX_fmt{ #*18?FMT[bkry
"
)
0
7
>
E
J
O
W
d
q
v
$+29@GNU\cjqx '.5<CJQX_fmt{ #*18?FMT[bipw~
&-4;BIPW^elsz !(/6=DOVcpuz-B\v$<Tdy*5@Tanz!2>O_fmt{ $-6?HQZclu~ )2;DMV^gpy $-6?HQZclu~ )2;DM\enwcommaaccentAbreveAmacronAogonekAEacuteCacuteCcaronCcircumflexCdotaccentDcaronDcroatEbreveEcaronEdotaccentEmacronEngEogonekGbreveGcircumflexGcommaaccentGdotaccentHbarHcircumflexIbreveIJImacronIogonekItildeJcircumflexKcommaaccentLacuteLcaronLcommaaccentLdotNacuteNcaronNcommaaccentObreveOhungarumlautOmacronOslashacuteRacuteRcaronRcommaaccentSacuteScedillaScircumflexScommaaccentTbarTcaronTcommaaccentUbreveUhungarumlautUmacronUogonekUringUtildeWacuteWcircumflexWdieresisWgraveYcircumflexYgraveZacuteZdotaccentIdotaccentabreveamacronaogonekaeacutecacuteccaronccircumflexcdotaccentdcarondcroatebreveecaronedotaccentemacronengeogonekgbrevegcircumflexgcommaaccentgdotaccenthbarhcircumflexibreveijimacroniogonekitildejcircumflexkcommaaccentlacutelcaronlcommaaccentldotnacutencaronncommaaccentobreveohungarumlautomacronoslashacuteracutercaronrcommaaccentsacutescedillascircumflexscommaaccenttbartcarontcommaaccentubreveuhungarumlautumacronuogonekuringutildewacutewcircumflexwdieresiswgraveycircumflexygravezacutezdotaccentkgreenlandiclongsnapostrophetonosdieresistonosAlphaBetaGammaDeltaEpsilonZetaEtaThetaIotaKappaLambdaMuNuXiOmicronPiRhoSigmaTauUpsilonPhiChiPsiOmegaAlphatonosEpsilontonosEtatonosIotatonosIotadieresisOmicrontonosUpsilontonosUpsilondieresisOmegatonosuni1FBBuni1F09uni1F0Duni1F0Buni1F0Funi1FB8uni1FBAuni1FBCuni1F89uni1F8Duni1F8Buni1F8Funi1F88uni1F8Cuni1F8Auni1F8Euni1F08uni1F0Cuni1F0Auni1F0Euni1FB9uni1FC9uni1F19uni1F1Duni1F1Buni1FC8uni1F18uni1F1Cuni1F1Auni1FCBuni1F29uni1F2Duni1F2Buni1F2Funi1FCAuni1FCCuni1F99uni1F9Duni1F9Buni1F9Funi1F98uni1F9Cuni1F9Auni1F9Euni1F28uni1F2Cuni1F2Auni1F2Euni1FDBuni1F39uni1F3Duni1F3Buni1F3Funi1FD8uni1FDAuni1F38uni1F3Cuni1F3Auni1F3Euni1FD9uni1FFBuni1F69uni1F6Duni1F6Buni1F6Funi1FFAuni1FFCuni1FA9uni1FADuni1FABuni1FAFuni1FA8uni1FACuni1FAAuni1FAEuni1F68uni1F6Cuni1F6Auni1F6Euni1FF9uni1F49uni1F4Duni1F4Buni1FF8uni1F48uni1F4Cuni1F4Auni1FECuni1FEBuni1F59uni1F5Duni1F5Buni1F5Funi1FE8uni1FEAuni1FE9alphabetagammadeltaepsilonzetaetathetaiotakappalambdanuxiomicronpirhosigmatauupsilonphichipsiomegaalphatonosepsilontonosetatonosiotatonosiotadieresisomicrontonosupsilontonosupsilondieresisomegatonosiotadieresistonosupsilondieresistonosuni03C2uni0374uni0375uni037Euni03D0uni03DAuni03DEuni03E0uni03F0uni1FBDuni1FBEuni1FC1uni1FCDuni1FCEuni1FCFuni1FDDuni1FDEuni1FDFuni1FEDuni1FEEuni1FFEuni1F00uni1F01uni1F02uni1F03uni1F04uni1F05uni1F06uni1F07uni1F10uni1F11uni1F12uni1F13uni1F14uni1F15uni1F20uni1F21uni1F22uni1F23uni1F24uni1F25uni1F26uni1F27uni1F30uni1F31uni1F32uni1F33uni1F34uni1F35uni1F36uni1F37uni1F40uni1F41uni1F42uni1F43uni1F44uni1F45uni1F50uni1F51uni1F52uni1F53uni1F54uni1F55uni1F56uni1F57uni1F60uni1F61uni1F62uni1F63uni1F64uni1F65uni1F66uni1F67uni1F70uni1F71uni1F72uni1F73uni1F74uni1F75uni1F76uni1F77uni1F78uni1F79uni1F7Auni1F7Buni1F7Cuni1F7Duni1F80uni1F81uni1F82uni1F83uni1F84uni1F85uni1F86uni1F87uni1F90uni1F91uni1F92uni1F93uni1F94uni1F95uni1F96uni1F97uni1FA0uni1FA1uni1FA2uni1FA3uni1FA4uni1FA5uni1FA6uni1FA7uni1FB0uni1FB1uni1FB2uni1FB3uni1FB6uni1FB7uni1FC2uni1FC3uni1FC4uni1FC6uni1FC7uni1FD0uni1FD1uni1FD2uni1FD3uni1FD6uni1FD7uni1FE0uni1FE1uni1FE2uni1FE3uni1FE4uni1FE5uni1FE6uni1FF2uni1FF3uni1FF4uni1FF6uni1FF7uni1FB4uni1FE7uniEFD5anoteleiauni03D1uni03D5uni03D6franclirapesetaEuroafii61289estimatedpartialdiffproductsummationuni2219radicalinfinityintegralapproxequalnotequallessequalgreaterequallozengeuni02C9uniEFEDuniEFEEuniEFF1uniEFF2uniEFF3uniEFF5uniEFF7AcuteCaronDieresisDieresisAcuteDieresisGraveGraveHungarumlautMacroncyrBrevecyrFlexdblGravecyrbrevecyrflexdblgravedieresisacutedieresisgraveuniF635uniF637uniF638uniF639uniF6DCuniF63AuniF63BuniF63CuniF63DuniF63EuniF63FuniF640uniF641uniF642uniF628uniF643uniF644uniF645uniF646uniF647uniF648uniF649uniF64AuniF64BuniF64CuniF64DuniF64EuniF64FuniF650uniF651uniF652uniF653uniF654uniF655uniF656uniF657uniF658uniF659uniF65AuniF65BuniF65CuniF65DuniF65EuniF65FuniF660uniF629uniF62AuniF62BuniF62CuniF62DuniF661uniF662uniF663uniF664uniF665uniF666uniF667uniF668uniF669uniF66AuniF66BuniF66CuniF62EuniF62FuniF630uniF631uniF632uniF66DuniF66EuniF66FuniF670uniF671uniF672uniF673uniF674uniF675uniF676uniF677uniF678uniF679uniF67AuniF67BuniF67CuniF67DuniF67EuniF67FuniF680uniF681uniF682uniF683uniF684uniF685uniF686uniF687uniF688uniF689uniF68AuniF68BuniF68CuniF68DuniF68EuniF68FuniF690uniF691uniF692uniF693uniF694uniF695uniF696uniF697uniF698uniF699uniF69AuniF69BuniF69CuniF69DuniF69EuniF69FuniF6A0uniF6A1uniF6A2uniF6A3uniF6A4uniF6A5uniF6A6uniF6A7uniF6A8uniF6A9uniF6AAuniF6ABuniF6ACuniF6ADuniF6AEuniF6AFuniF6B0uniF6B1uniF6B2uniF6B3uniF6B4uniF6B5uniF6B6uniF6B7uniF6B8uniF6B9uniF6BAuniF6BBuniF6BCuniF6BDuniF633c_hc_kc_tf_bf_f_bf_f_hf_f_kf_f_tf_hf_jf_f_jf_kf_ts_puniFB06T_hlongs_blongs_hlongs_ilongs_klongs_llongs_longsuniFB05longs_longs_ilongs_longs_la.ende.endm.endn.endr.endK.altR.altk.altcaron.altcommaaccent.altpeseta.altAlphaiotasub.altAlphaiotasubasper.altAlphaiotasubasperacute.altAlphaiotasubaspergrave.altAlphaiotasubaspertilde.altAlphaiotasublenis.altAlphaiotasublenisacute.altAlphaiotasublenisgrave.altAlphaiotasublenistilde.altEtaiotasub.altEtaiotasubasper.altEtaiotasubasperacute.altEtaiotasubaspergrave.altEtaiotasubaspertilde.altEtaiotasublenis.altEtaiotasublenisacute.altEtaiotasublenisgrave.altEtaiotasublenistilde.altOmegaiotasub.altOmegaiotasubasper.altOmegaiotasubasperacute.altOmegaiotasubaspergrave.altOmegaiotasubaspertilde.altOmegaiotasublenis.altOmegaiotasublenisacute.altOmegaiotasublenisgrave.altOmegaiotasublenistilde.altEuro.fittedcent.fittedcolonmonetary.fitteddollar.fittedflorin.fittedfranc.fittedlira.fittednumbersign.fittedsterling.fittedyen.fittedEuro.oldstylecolonmonetary.oldstyleestimated.oldstyleflorin.oldstylefranc.oldstylelira.oldstylenumbersign.oldstylesterling.oldstyleyen.oldstylefranc.taboldstylelira.taboldstyleorn.001orn.002orn.003orn.004orn.005orn.006orn.007orn.008orn.009orn.010orn.011orn.012orn.013orn.014orn.015orn.016orn.017orn.018orn.019orn.020orn.021orn.022orn.023afii10023afii10031afii10022afii10049T_h.caronafii10070afii10196afii10026afii10021afii10846afii10193afii10107afii10024afii10195afii10041afii10037afii10109afii10053afii10045afii10108afii10040afii10104afii10036afii10078afii10074afii10060afii10046afii10052afii10087afii10050afii10145afii10057afii10059afii10146afii10088afii10101afii10054afii10058Rholenisafii10025afii10099afii10068afii10035afii10048afii10089afii10105afii10085afii10020afii10077afii10106afii10019afii10076afii10110afii10100afii10090afii10028afii10095afii10147afii10066afii10098afii10082afii10061afii10103afii10102afii10083afii10027afii10072afii10039afii61352afii10069afii10094afii10038afii10034afii10148afii10032afii10194afii10033afii10075afii10017afii10081afii10056afii10084afii10044afii10030afii10051afii10047afii10018afii10080afii10042afii10071afii10029afii10062afii10065afii10097T_h.commaaccentafii10096afii10079afii10091afii10093afii10064afii10043afii10092uni2215uni021Bafii10073afii10067uni00A0uni021Aafii10086afii10055uni0394uni03BCuni03A9uni00ADCopyright 2000 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604.Minion is either a registered trademark or a trademark of Adobe Systems Incorporated in the United States and/or other countries.Minion Pro RegularMinion Pro% i WZ5:`v22> % I
/
2
I
o
#3p~U
D
e
!o#]emE %<Jeov~EMfjtFp|,S-AZ0=DK +^&7NQy(/S_dl 5Rk$=Valsz"'-@T_gos{ ) . > N ^ d n v ~ !!!!'!3!?!H!Q!Z!]!c!i!n!s!x!!!!!!!!!!!!!"""#"'"3"?"K"W"c"k"s"{""""""""""""""c&oEr^7 JB@H *W2c~sp&m!1= 4:$kYyywRvzwrZnon?˘iNUddLoLݪ
~}}vywS6vO(Zp^TrǕ؍8x`?NYwUVYWE}zyMhummR~Kfowx}|txcBzuyBpOwTxql[LPҩy}~Bxxhzqlc#T0@9
5/j,X^M8Uruuoquvqiff{bE<H8XUo^bb_rMG'Н=[W}yQSSۚ$P|TzTyT'
ajqyzx||rrpwttozpj`lWHrʥaiqyo
|rqpxt@tpyqjalVHr]yt/m'mDx]pIsn8AgmxpQAz4wv~s}~vstzf|oęgfeoszvwzxu$wny|YgJO-ʆea]>9+ZhchAB_\?#^|m[5v-<<[FL LHHq˂~XxAo4uFabfqaf%f+rrs}ǔcqW "* ڟŇՊvx|po~}wUJN<0o-כtzr[ {"!coч~^o]/6'orsBp0ZlZqRoGt{_Fpq|iiMkTratap`DabuvCICpAϦ{~{lpˇBDDpӐ qoكtYoNU)gI_Z`yӔodžF/INlw71oC
ŸԱȗГnoՆ3$811xrdcQD:0] ;hJjp~djmplXhZfYxnmmyf^#MR:AgszvT]jjZ?_ynZQ{sNHyZdƨ]O틯֯}ޣDyZ{kvumofFMk_VYЄ#ms^@L A_!Z Z|蒯}~rqyg|usqrwgmazԬqbfZBoل5|%69o<3oZMZJuׇ3c T{ddmvrjY_VpŇkrkGpφ}8Fgsmy]pWSy/OBR7WXjfeolw}v84o~}xUGP~72pC
~㿊IK
NϪb98IPq
`y[~XsłI\FL
ދ.R۲vhl_@oۅ8(85oq͗ƫ>(3XOG7]_\i^%"Ba:Jy.}eu}|wzq]is|~ґϐuCDDEp
ؑ~P|xhcMp^},
qkuGuzwv~s}~ust}e{nęgfR5BcH
蠓`
i
`c
v
y
蠚}xsnyvrpyh&T~Y|S|Q4xrqxvrpyhrqVVrm