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Gianni Biolo, Benedetta Massolino, Filippo Giorgio Di Girolamo, Nicola Fiotti, Filippo Mearelli, Sara Mazzucco, Carlos Bertuzzi, Renzo Lazzarini, Alfonso Colombatti, Marcello De Cicco
Intensive insulin therapy increases glutathione synthesis rate in surgical ICU patients with stress hyperglycemia
www.plosone.org
www.plosone.org
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(end-points)Tj
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(would)Tj
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(have)Tj
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(design:)Tj
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(experimental)Tj
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(previous)Tj
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(paper)Tj
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(25)Tj
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(all)Tj
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(patients)Tj
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(continuous)Tj
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(\(20%)Tj
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(solution)Tj
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(at)Tj
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(20)Tj
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(mL/kg/day\),)Tj
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(lipids)Tj
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(10%)Tj
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(8)Tj
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(mL/kg/day\))Tj
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(mixed)Tj
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(amino)Tj
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(acids)Tj
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(at)Tj
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(14.4)Tj
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(mL/kg/day\),)Tj
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(a)Tj
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(total)Tj
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(energy)Tj
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(intake)Tj
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(experi-)Tj
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(procedure)Tj
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(Fig)Tj
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(1)Tj
0 g
(\))Tj
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(the)Tj
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(2)Tj
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(PM,)Tj
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(the)Tj
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(next)Tj
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(assigned,)Tj
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(according)Tj
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(a)Tj
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(randomized)Tj
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(crossover)Tj
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(design,)Tj
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(either)Tj
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(IIT)Tj
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(\(insulin)Tj
3.3278 0 Td
(infused)Tj
3.1635 0 Td
(if)Tj
0.7767 0 Td
(glycaemia)Tj
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0 Tc
4.1895 0 Td
(>)Tj
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-0.004 Tc
0.9865 0 Td
(6.1)Tj
1.4003 0 Td
(mmol/L)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 386.1354 446.6834 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(,)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 389.9905 448.3842 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(at)Tj
0.9524 0 Td
(dosages)Tj
3.2995 0 Td
(adjusted)Tj
3.5773 0 Td
(to)Tj
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(maintain)Tj
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(euglycaemia)Tj
-31.691 -1.3039 Td
(between)Tj
3.5263 0 Td
(4.46.9)Tj
3.0897 0 Td
(mmol/L\))Tj
3.8211 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(3)Tj
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(])Tj
2.0806 0 Td
(or)Tj
1.0942 0 Td
(CIT,)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(control)Tj
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(treatment)Tj
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(\(insulin)Tj
3.3222 0 Td
(given)Tj
2.3811 0 Td
(if)Tj
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(glycaemia)Tj
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0 Tc
4.1895 0 Td
(>)Tj
/F6 1 Tf
-0.004 Tc
0.9865 0 Td
(9.4)Tj
-35.6028 -1.2982 Td
(mmol/L)Tj
3.4809 0 Td
(at)Tj
0.9524 0 Td
(dosages)Tj
3.2995 0 Td
(adjusted)Tj
3.5717 0 Td
(to)Tj
1.0261 0 Td
(maintain)Tj
3.8381 0 Td
(a)Tj
0.6576 0 Td
(moderate)Tj
4.0194 0 Td
(hyperglycaemia,)Tj
6.7124 0 Td
(between)Tj
3.5263 0 Td
(8.311.1)Tj
3.566 0 Td
(mmol/)Tj
-34.6504 -1.2983 Td
(L\).)Tj
1.3209 0 Td
(Five)Tj
1.8935 0 Td
(cases)Tj
2.2224 0 Td
(followed)Tj
3.651 0 Td
(protocol)Tj
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(1)Tj
0.6916 0 Td
(\(i.e.)Tj
1.7008 0 Td
(IIT)Tj
1.5137 0 Td
(first,)Tj
2.0296 0 Td
(CIT)Tj
1.8367 0 Td
(second\))Tj
3.3505 0 Td
(and)Tj
1.7292 0 Td
(5)Tj
0.6973 0 Td
(cases)Tj
2.2223 0 Td
(protocol)Tj
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(2)Tj
0.6974 0 Td
(\(i.e.)Tj
1.7007 0 Td
(CIT)Tj
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(first,)Tj
2.0296 0 Td
(IIT)Tj
1.5137 0 Td
(second\).)Tj
3.5716 0 Td
(Such)Tj
2.177 0 Td
(a)Tj
0.6519 0 Td
(randomization)Tj
6.1682 0 Td
(was)Tj
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(performed)Tj
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(to)Tj
1.0205 0 Td
(account)Tj
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(for)Tj
1.3889 0 Td
(possible)Tj
3.4073 0 Td
(time-related)Tj
-31.4813 -1.2983 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(glutathione)Tj
4.7622 0 Td
(kinetics)Tj
3.3052 0 Td
(and)Tj
1.7291 0 Td
(oxidative)Tj
3.8664 0 Td
(stress,)Tj
2.6191 0 Td
(after)Tj
2.0353 0 Td
(surgery,)Tj
3.4242 0 Td
(and)Tj
1.7291 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(potential)Tj
3.7587 0 Td
(risks)Tj
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(of)Tj
-36.6006 -1.2982 Td
(interference)Tj
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(between)Tj
3.532 0 Td
(the)Tj
1.4683 0 Td
(two)Tj
1.7064 0 Td
(stable)Tj
2.4888 0 Td
(isotope)Tj
3.1011 0 Td
(infusions,)Tj
4.1215 0 Td
(administered)Tj
5.4935 0 Td
(with)Tj
1.9956 0 Td
(such)Tj
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(a)Tj
0.6576 0 Td
(tight)Tj
2.075 0 Td
(schedule)Tj
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([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
2.0749 0 Td
(Throughout)Tj
5.091 0 Td
(the)Tj
1.4684 0 Td
(2-day)Tj
2.4661 0 Td
(insulin)Tj
2.982 0 Td
(infusion)Tj
3.5376 0 Td
(study,)Tj
2.6134 0 Td
(glycaemia)Tj
4.1896 0 Td
(was)Tj
1.7008 0 Td
(assessed)Tj
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(every)Tj
2.3471 0 Td
(2)Tj
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(hours.)Tj
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(The)Tj
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(stable)Tj
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(isotope)Tj
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(infusion)Tj
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(to)Tj
1.0261 0 Td
(determine)Tj
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(erythrocyte)Tj
4.7734 0 Td
(glutathione)Tj
4.7622 0 Td
(kinetics)Tj
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(and)Tj
1.7348 0 Td
(oxidative)Tj
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(stress,)Tj
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(was)Tj
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(performed)Tj
4.4673 0 Td
(during)Tj
2.9311 0 Td
(the)Tj
1.4683 0 Td
(last)Tj
1.559 0 Td
(7)Tj
0.6974 0 Td
(h)Tj
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(of)Tj
1.0148 0 Td
(insulin)Tj
2.9877 0 Td
(treatment)Tj
4.1385 0 Td
(\(from)Tj
2.5455 0 Td
(7)Tj
0.6916 0 Td
(AM)Tj
1.7972 0 Td
(to)Tj
1.0261 0 Td
(2)Tj
0.6973 0 Td
(PM\),)Tj
2.2394 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
2.0636 0 Td
(IIT)Tj
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(or)Tj
1.0999 0 Td
(CIT)Tj
-34.7071 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
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(In)Tj
1.1112 0 Td
(order)Tj
2.4208 0 Td
(to)Tj
1.0261 0 Td
(assess)Tj
2.5172 0 Td
(clinical)Tj
3.0784 0 Td
(stability)Tj
3.3505 0 Td
(between)Tj
3.5318 0 Td
(the)Tj
1.4684 0 Td
(two)Tj
1.7121 0 Td
(isotope)Tj
3.0954 0 Td
(infusions,)Tj
4.1215 0 Td
(hemodynamic)Tj
5.9754 0 Td
(indi-)Tj
-35.4837 -1.3039 Td
(ces)Tj
1.4286 0 Td
(\(systolic)Tj
3.4753 0 Td
(and)Tj
1.7291 0 Td
(diastolic)Tj
3.5546 0 Td
(arterial)Tj
3.0671 0 Td
(pressure,)Tj
3.7984 0 Td
(heart)Tj
2.2789 0 Td
(rate)Tj
1.7462 0 Td
(and)Tj
1.7291 0 Td
(hematocrit\))Tj
4.9322 0 Td
(and)Tj
1.7292 0 Td
(plasma)Tj
3.033 0 Td
(creatinine)Tj
-32.5017 -1.2982 Td
(concentrations,)Tj
6.4062 0 Td
(were)Tj
2.1203 0 Td
(determined)Tj
4.8529 0 Td
(before)Tj
2.7383 0 Td
(starting)Tj
3.2654 0 Td
(the)Tj
1.4683 0 Td
(infusion)Tj
3.5319 0 Td
(procedures.)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 264.2522 m
576 264.2522 l
576 263.7522 l
36 263.7522 l
f*
113.811 263.7522 m
113.811 241.7522 l
113.311 241.7522 l
113.311 263.7522 l
f*
113.311 241.7522 m
36 241.7522 l
36 242.2522 l
113.311 242.2522 l
f*
195.9511 263.7522 m
195.9511 241.7522 l
195.4511 241.7522 l
195.4511 263.7522 l
f*
195.4511 241.7522 m
113.811 241.7522 l
113.811 242.2522 l
195.4511 242.2522 l
f*
267.3754 263.7522 m
267.3754 241.7522 l
266.8754 241.7522 l
266.8754 263.7522 l
f*
266.8754 241.7522 m
195.9511 241.7522 l
195.9511 242.2522 l
266.8754 242.2522 l
f*
348.8374 263.7522 m
348.8374 241.7522 l
348.3374 241.7522 l
348.3374 263.7522 l
f*
348.3374 241.7522 m
267.3754 241.7522 l
267.3754 242.2522 l
348.3374 242.2522 l
f*
486.5647 263.7522 m
486.5647 241.7522 l
486.0646 241.7522 l
486.0646 263.7522 l
f*
486.0646 241.7522 m
348.8374 241.7522 l
348.8374 242.2522 l
486.0646 242.2522 l
f*
575.9997 241.7522 m
486.5647 241.7522 l
486.5647 242.2522 l
575.9997 242.2522 l
f*
113.811 241.7522 m
113.811 229.2523 l
113.311 229.2523 l
113.311 241.7522 l
f*
113.311 229.2523 m
36 229.2523 l
36 229.7523 l
113.311 229.7523 l
f*
195.9511 241.7522 m
195.9511 229.2523 l
195.4511 229.2523 l
195.4511 241.7522 l
f*
195.4511 229.2523 m
113.811 229.2523 l
113.811 229.7523 l
195.4511 229.7523 l
f*
267.3754 241.7522 m
267.3754 229.2523 l
266.8754 229.2523 l
266.8754 241.7522 l
f*
266.8754 229.2523 m
195.9511 229.2523 l
195.9511 229.7523 l
266.8754 229.7523 l
f*
348.8374 241.7522 m
348.8374 229.2523 l
348.3374 229.2523 l
348.3374 241.7522 l
f*
348.3374 229.2523 m
267.3754 229.2523 l
267.3754 229.7523 l
348.3374 229.7523 l
f*
486.5647 241.7522 m
486.5647 229.2523 l
486.0646 229.2523 l
486.0646 241.7522 l
f*
486.0646 229.2523 m
348.8374 229.2523 l
348.8374 229.7523 l
486.0646 229.7523 l
f*
575.9997 229.2523 m
486.5647 229.2523 l
486.5647 229.7523 l
575.9997 229.7523 l
f*
113.811 229.2523 m
113.811 216.7523 l
113.311 216.7523 l
113.311 229.2523 l
f*
113.311 216.7523 m
36 216.7523 l
36 217.2523 l
113.311 217.2523 l
f*
195.9511 229.2523 m
195.9511 216.7523 l
195.4511 216.7523 l
195.4511 229.2523 l
f*
195.4511 216.7523 m
113.811 216.7523 l
113.811 217.2523 l
195.4511 217.2523 l
f*
267.3754 229.2523 m
267.3754 216.7523 l
266.8754 216.7523 l
266.8754 229.2523 l
f*
266.8754 216.7523 m
195.9511 216.7523 l
195.9511 217.2523 l
266.8754 217.2523 l
f*
348.8374 229.2523 m
348.8374 216.7523 l
348.3374 216.7523 l
348.3374 229.2523 l
f*
348.3374 216.7523 m
267.3754 216.7523 l
267.3754 217.2523 l
348.3374 217.2523 l
f*
486.5647 229.2523 m
486.5647 216.7523 l
486.0646 216.7523 l
486.0646 229.2523 l
f*
486.0646 216.7523 m
348.8374 216.7523 l
348.8374 217.2523 l
486.0646 217.2523 l
f*
575.9997 216.7523 m
486.5647 216.7523 l
486.5647 217.2523 l
575.9997 217.2523 l
f*
113.811 216.7523 m
113.811 204.2524 l
113.311 204.2524 l
113.311 216.7523 l
f*
113.311 204.2524 m
36 204.2524 l
36 204.7524 l
113.311 204.7524 l
f*
195.9511 216.7523 m
195.9511 204.2524 l
195.4511 204.2524 l
195.4511 216.7523 l
f*
195.4511 204.2524 m
113.811 204.2524 l
113.811 204.7524 l
195.4511 204.7524 l
f*
267.3754 216.7523 m
267.3754 204.2524 l
266.8754 204.2524 l
266.8754 216.7523 l
f*
266.8754 204.2524 m
195.9511 204.2524 l
195.9511 204.7524 l
266.8754 204.7524 l
f*
348.8374 216.7523 m
348.8374 204.2524 l
348.3374 204.2524 l
348.3374 216.7523 l
f*
348.3374 204.2524 m
267.3754 204.2524 l
267.3754 204.7524 l
348.3374 204.7524 l
f*
486.5647 216.7523 m
486.5647 204.2524 l
486.0646 204.2524 l
486.0646 216.7523 l
f*
486.0646 204.2524 m
348.8374 204.2524 l
348.8374 204.7524 l
486.0646 204.7524 l
f*
575.9997 204.2524 m
486.5647 204.2524 l
486.5647 204.7524 l
575.9997 204.7524 l
f*
113.811 204.2524 m
113.811 191.7524 l
113.311 191.7524 l
113.311 204.2524 l
f*
113.311 191.7524 m
36 191.7524 l
36 192.2525 l
113.311 192.2525 l
f*
195.9511 204.2524 m
195.9511 191.7524 l
195.4511 191.7524 l
195.4511 204.2524 l
f*
195.4511 191.7524 m
113.811 191.7524 l
113.811 192.2525 l
195.4511 192.2525 l
f*
267.3754 204.2524 m
267.3754 191.7524 l
266.8754 191.7524 l
266.8754 204.2524 l
f*
266.8754 191.7524 m
195.9511 191.7524 l
195.9511 192.2525 l
266.8754 192.2525 l
f*
348.8374 204.2524 m
348.8374 191.7524 l
348.3374 191.7524 l
348.3374 204.2524 l
f*
348.3374 191.7524 m
267.3754 191.7524 l
267.3754 192.2525 l
348.3374 192.2525 l
f*
486.5647 204.2524 m
486.5647 191.7524 l
486.0646 191.7524 l
486.0646 204.2524 l
f*
486.0646 191.7524 m
348.8374 191.7524 l
348.8374 192.2525 l
486.0646 192.2525 l
f*
575.9997 191.7524 m
486.5647 191.7524 l
486.5647 192.2525 l
575.9997 192.2525 l
f*
113.811 191.7524 m
113.811 179.2525 l
113.311 179.2525 l
113.311 191.7524 l
f*
113.311 179.2525 m
36 179.2525 l
36 179.7525 l
113.311 179.7525 l
f*
195.9511 191.7524 m
195.9511 179.2525 l
195.4511 179.2525 l
195.4511 191.7524 l
f*
195.4511 179.2525 m
113.811 179.2525 l
113.811 179.7525 l
195.4511 179.7525 l
f*
267.3754 191.7524 m
267.3754 179.2525 l
266.8754 179.2525 l
266.8754 191.7524 l
f*
266.8754 179.2525 m
195.9511 179.2525 l
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f*
348.8374 191.7524 m
348.8374 179.2525 l
348.3374 179.2525 l
348.3374 191.7524 l
f*
348.3374 179.2525 m
267.3754 179.2525 l
267.3754 179.7525 l
348.3374 179.7525 l
f*
486.5647 191.7524 m
486.5647 179.2525 l
486.0646 179.2525 l
486.0646 191.7524 l
f*
486.0646 179.2525 m
348.8374 179.2525 l
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486.0646 179.7525 l
f*
575.9997 179.2525 m
486.5647 179.2525 l
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