In this work, a study has been carried out to prepare drug-polymer composites of Cefuroxime Axetil amorphous (CFA, antibiotic) loaded Polyvinylpyrrolidone (PVP-K30) by batch and continuous supercritical antisolvent (SAS) process. Solutions of (CFA + PVP-K30) in methanol or dichloromethane with overall concentrations of 50-150 mg/ml and drug/polymer ratios of 1/1-1/4 were sprayed with flow rates of 0.85-6 ml/min into the scCO2 at 100-150 bar and 35-50 °C. The effects of the process mode on the properties of the composite particles have been investigated. DSC, XRD and SEM analyses have been carried out to enlighten the particle formation mechanisms of two processes and to determine the relationship between the mechanism and product properties.
Effect of the Process Mode on the Properties of the Drug-Polymer Composite Particles Prepared by SAS Process.
ALESSI, PAOLO;KIKIC, IRENEO;DE ZORDI, NICOLA;MONEGHINI, MARIAROSA;SOLINAS, DARIO;
2010-01-01
Abstract
In this work, a study has been carried out to prepare drug-polymer composites of Cefuroxime Axetil amorphous (CFA, antibiotic) loaded Polyvinylpyrrolidone (PVP-K30) by batch and continuous supercritical antisolvent (SAS) process. Solutions of (CFA + PVP-K30) in methanol or dichloromethane with overall concentrations of 50-150 mg/ml and drug/polymer ratios of 1/1-1/4 were sprayed with flow rates of 0.85-6 ml/min into the scCO2 at 100-150 bar and 35-50 °C. The effects of the process mode on the properties of the composite particles have been investigated. DSC, XRD and SEM analyses have been carried out to enlighten the particle formation mechanisms of two processes and to determine the relationship between the mechanism and product properties.Pubblicazioni consigliate
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