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Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells

Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain. Being present at the mucosal surfaces, SP-D acts as a potent innate immune molecule and offers protection against non-self and altered self, such as pathogens, allergens, and tumor. Here, we examined the effect of a recombinant fragment of human SP-D (rfhSP-D) on a range of breast cancer lines. Breast cancer h...

Evidence of diaphragmatic dysfunction with severe alveolar hypoventilation syndrome in mitochondrial respiratory chain deficiency

Diaphragmatic dysfunction has been reported in congenital myopathies, muscular dystrophies, and occasionally, mitochondrial respiratory chain deficiency. Using a minimally invasive procedure in 3 young girls, 1 with a heteroplasmic MT-CYB mutation and 2 with biallelic pathogenic TK2 variants, we provided functional evidence of diaphragmatic dysfunction with global respiratory muscle weakness in mitochondrial respiratory chain deficiency. Analysis of respiratory muscle performance using esogas...

Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases

The crucial physiological process of heme breakdown yields biliverdin (BV) and bilirubin (BR) as byproducts. BV, BR, and the enzymes involved in their production (the “yellow players—YP”) are increasingly documented as endogenous modulators of human health. Mildly elevated serum bilirubin concentration has been correlated with a reduced risk of multiple chronic pro-oxidant and pro-inflammatory diseases, especially in the elderly. BR and BV per se have been demonstrated to protect against neur...

Inflammation, Dopaminergic Brain and Bilirubin

Dopamine is a well-known neurotransmitter due to its involvement in Parkinson’s disease (PD). Dopamine is not only involved in PD but also controls multiple mental and physical activities, such as the pleasure of food, friends and loved ones, music, art, mood, cognition, motivation, fear, affective disorders, addiction, attention deficit disorder, depression, and schizophrenia. Dopaminergic neurons (DOPAn) are susceptible to stressors, and inflammation is a recognized risk for neuronal malfun...

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report that pharmacological CDK12/CDK13 inhibition (CDK12i) synergistically enhances PT-induced cytotoxicity in a large number of PT-sensitive and PT-resistant EOC models. CDK12i effect...

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Tipologia
  • 1 Contributo in Rivista(Articolo ...68079
  • 2 Contributo in Volume17121
  • 4 Contributo in convegno non pubb...11703
  • 3 Libro (Monografia)3106
  • 7 Altro3080
  • 6 Curatela1713
  • 4 Contributo in Atti Convegno1354
  • 8 Tesi1337
  • 5 Brevetto199
Autore
  • DELLA RICCA, GIUSEPPE2251
  • GONELLA, LAURA1391
  • CANDELISE, VIERI1349
  • SINAGRA, GIANFRANCO1253
  • PAVANELLO, GIUSEPPE1007
  • VITALE, LORENZO1004
  • LANCERI, LIVIO876
  • PRATO, MAURIZIO803
  • ZALAUDEK, IRIS797
  • LONGO, FRANCESCO724
Data di pubblicazione
  • In corso di stampa102
  • 2020 - 202723914
  • 2010 - 201937108
  • 2000 - 200928035
  • 1990 - 199912921
  • 1980 - 19894730
  • 1970 - 19791242
  • 1961 - 196952
Editore
  • Università degli Studi di Trieste1372
  • IEEE780
  • Springer663
  • EUT586
  • EUT Edizioni Università di Trieste449
  • Franco Angeli415
  • Giappichelli346
  • Springer Verlag323
  • Alfieri306
  • -289
Rivista
  • PHYSICS LETTERS. SECTION B1164
  • JOURNAL OF HIGH ENERGY PHYSICS1060
  • PHYSICAL REVIEW LETTERS939
  • THE EUROPEAN PHYSICAL JOURNAL. C,...707
  • ASTRONOMY & ASTROPHYSICS662
  • PHYSICAL REVIEW D, PARTICLES, FIE...577
  • MONTHLY NOTICES OF THE ROYAL ASTR...576
  • PHYSICAL REVIEW D461
  • THE ASTROPHYSICAL JOURNAL435
  • NUCLEAR INSTRUMENTS & METHODS IN ...427
Serie
  • LECTURE NOTES IN COMPUTER SCIENCE125
  • LECTURE NOTES IN ARTIFICIAL INTEL...76
  • BIBLIOTECA DELLA SOCIETÀ APERTA. ...60
  • CEUR WORKSHOP PROCEEDINGS49
  • OMNIA43
  • IFMBE PROCEEDINGS36
  • POLYMNIA. STUDI DI ARCHEOLOGIA34
  • STRUMENTI DI UMANISTICA DIGITALE32
  • SOCIETÀ ITALIANA DI PEDAGOGIA28
  • LECTURE NOTES IN COMPUTER SCIENCE26
Settore disciplinare
  • Settore FIS/03 - Fisica della Mat...126
  • Settore CHIM/06 - Chimica Organica85
  • Settore BIO/11 - Biologia Molecolare48
  • Settore BIO/07 - Ecologia40
  • Settore MED/38 - Pediatria Genera...37
  • Settore BIO/10 - Biochimica36
  • Settore FIS/05 - Astronomia e Ast...33
  • Settore INF/01 - Informatica32
  • Settore FIS/01 - Fisica Sperimentale30
  • Settore ICAR/01 - Idraulica27
Keyword
  • Humans2335
  • PARTICLE PHYSICS2266
  • LARGE HADRON COLLIDER1543
  • CMS1539
  • Female1158
  • Male1109
  • -763
  • Italy666
  • Middle Aged657
  • Adult648
Lingua
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  • ita29564
  • fre1049
  • ger729
  • spa723
  • slv388
  • rus369
  • grc176
  • lat84
  • hrv66
Accesso al fulltext
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  • open18057
  • reserved14660
  • partially open4720
  • embargoed89
  • mixed5