The purpose of this study is to investigate the influence of supercritical CO2 on the physicochemical properties of Piroxicam (PXC), a poorly soluble drug. The supercritical anti-solvent (SAS) technique was used to precipitate the drug at the pressure of 100 and 120 bar from three different solvents (acetone, ethylacetate and dichloromethane) to study how they would affect the final product. The samples were analyzed before and after the treatment to highlight possible changes in the habitus of the crystals.
Supercritical Antisolvent Precipitation of Piroxicam Systems: Preliminary Experiments.
DE ZORDI, NICOLA;MONEGHINI, MARIAROSA;KIKIC, IRENEO;SOLINAS, DARIO
2010-01-01
Abstract
The purpose of this study is to investigate the influence of supercritical CO2 on the physicochemical properties of Piroxicam (PXC), a poorly soluble drug. The supercritical anti-solvent (SAS) technique was used to precipitate the drug at the pressure of 100 and 120 bar from three different solvents (acetone, ethylacetate and dichloromethane) to study how they would affect the final product. The samples were analyzed before and after the treatment to highlight possible changes in the habitus of the crystals.File in questo prodotto:
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