Surfaces engineering approaches for cell culture substrates using biomimetic Human Elastin-Like Polypeptides

Spatially controlled cell adhesion and multicellular organization is critical to many biomedical and tissue-engineering applications. Many efforts have therefore focused on the production of engineered surfaces that can promote, and possibly control, cell adhesion and growth. Here we present the characterization of these spontaneously formed patterns using HELP-fluoresceinated derivatives. The ability to support cell adhesion and growth of the HELP-based substrates is also explored.