Poster presentato all'AIChE Annual Meeting (CD), San Francisco (CA – USA), 16-21 novembre 2003, 284d. - Atenolol is a β-blockers drug commonly used in the prevention of heart diseases. The aim of this work is to improve his bioavailability modifying his particle size. Saturation conditions, at different temperatures, for systems made up with carbon dioxide and solutions of atenolol in methanol, ethanol and isopropanol have been investigated using a variable volume cell. Atenolol was precipitated from different solutions (5% w/w atenolol-methanol, 5%w/w atenolol-ethanol and 1,65% w/w atenolol/isopropanol) using supercritical carbon dioxide as antisolvent agent. The release profiles of the micronized atenolol show a general enhancement of the dissolution rate, compared to the one of the untreated drug.
Supercritical Antisolvent Processing of Atenolol
KIKIC, IRENEO;ALESSI, PAOLO;CORTESI, ANGELO;EVA, FABIANA
2003-01-01
Abstract
Poster presentato all'AIChE Annual Meeting (CD), San Francisco (CA – USA), 16-21 novembre 2003, 284d. - Atenolol is a β-blockers drug commonly used in the prevention of heart diseases. The aim of this work is to improve his bioavailability modifying his particle size. Saturation conditions, at different temperatures, for systems made up with carbon dioxide and solutions of atenolol in methanol, ethanol and isopropanol have been investigated using a variable volume cell. Atenolol was precipitated from different solutions (5% w/w atenolol-methanol, 5%w/w atenolol-ethanol and 1,65% w/w atenolol/isopropanol) using supercritical carbon dioxide as antisolvent agent. The release profiles of the micronized atenolol show a general enhancement of the dissolution rate, compared to the one of the untreated drug.Pubblicazioni consigliate
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