Differences in fixation and IHC and subjective interpretation can substantially affect the accuracy and reproducibility of estrogen receptor (ER), progesterone receptor (PR) and HER2 expression. The commercially available TargetPrint test measures the mRNA expression level of ER, PR and HER2 and is 98% concordant with centrally assessed ER as presented by Viale et al, SABCS 2011. This study compares results from the microarray-based TargetPrint with IHC and FISH (for HER2 IHC2+) generated by local standard procedures
Central review of discordant samples for microarray based on ER, PR, and HER2 and local IHC/FISH assessment worldwide from 827 patients / Wesseling, J.; Sapino, A.; Zanconati, Fabrizio; Lutke Holzik, M.; Nguyen, B.; Deck, B.; Querzoli, P.; Perin, T.; Giardina, C.; Seitz, G.; Guinebretiere, J.; Barone, J.; Watanabe, T.; De Snoo, F.; Stork Sloots, L.; Cusumano, P.. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - STAMPA. - (2012), pp. 10554-10554. ( 2012 ASCO Annual Meeting Chicago 1-5 giugno 2012).
Central review of discordant samples for microarray based on ER, PR, and HER2 and local IHC/FISH assessment worldwide from 827 patients.
ZANCONATI, FABRIZIO;
2012-01-01
Abstract
Differences in fixation and IHC and subjective interpretation can substantially affect the accuracy and reproducibility of estrogen receptor (ER), progesterone receptor (PR) and HER2 expression. The commercially available TargetPrint test measures the mRNA expression level of ER, PR and HER2 and is 98% concordant with centrally assessed ER as presented by Viale et al, SABCS 2011. This study compares results from the microarray-based TargetPrint with IHC and FISH (for HER2 IHC2+) generated by local standard proceduresPubblicazioni consigliate
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