On the basis of some benzo[d]oxazol-2(3H)-one derivatives previously developed by us and gifted with excellent σ1 affinity and selectivity, we have synthesized a new series of compounds 1 and 2, changing the benzoxazolone moiety with similar groups to evaluate their effects toward the sigma affinity and selectivity. The preliminary docking study (Fig.1), confirm the interactions between the structure of our new derivative and the features of the σ1 3D-receptor model.
New heterocyclic derivatives of benzylpiperidin-4-yl methyl and benzyl(methyl)aminobutyl sequences as sigma ligands.
ZAMPIERI, DANIELE;LAURINI, ERIK;VIO, LUCIANO;MAMOLO, MARIA GRAZIA
2013-01-01
Abstract
On the basis of some benzo[d]oxazol-2(3H)-one derivatives previously developed by us and gifted with excellent σ1 affinity and selectivity, we have synthesized a new series of compounds 1 and 2, changing the benzoxazolone moiety with similar groups to evaluate their effects toward the sigma affinity and selectivity. The preliminary docking study (Fig.1), confirm the interactions between the structure of our new derivative and the features of the σ1 3D-receptor model.File in questo prodotto:
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