In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

KIKIC, IRENEO;MONEGHINI, MARIAROSA;DE ZORDI, NICOLA;SOLINAS, DARIO;
2013

Abstract

In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/2797123
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