Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.



Titolo: Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation
Autori: 
KIKIC, IRENEO
MONEGHINI, MARIAROSA
DE ZORDI, NICOLA
SOLINAS, DARIO
mostra contributor esterni 
Data di pubblicazione: 2013
Abstract: In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.
Handle: http://hdl.handle.net/11368/2797123
Appare nelle tipologie:4.2 Abstract

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http://hdl.handle.net/11368/2797123
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