In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.
Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation / P., Marizza; S. S., Keller; T., Rades; A., Müllertz; Kikic, Ireneo; Moneghini, Mariarosa; DE ZORDI, Nicola; Solinas, Dario; A., Boisen. - ELETTRONICO. - (2013), pp. 1-1. ( 40th Annual Meeting & Exposition of the Controlled Release Society Honolulu, Hawaii, U.S.A. July 21-24, 2013).
Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation
KIKIC, IRENEO;MONEGHINI, MARIAROSA;DE ZORDI, NICOLA;SOLINAS, DARIO;
2013-01-01
Abstract
In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
