The detection of hepatocellular carcinoma (HCC) may be improved by analyzing the novel class of serumbiomarkers constituted by IgM immune complexes of well-known cancer antigens such as alpha-fetoprotein (AFP-IgM). To evaluate the relevance of the natural immune response to AFP for HCC diagnosis, we assessed the levels of IgM anti-AFP antibodies in serum samples of patients with HCC and with cirrhosis (CR) using a dedicated IgM anti-AFP assay. The assay result was compared to the diagnostic accuracy of the AFP-IgM test.
Improved detection of HCC by co-determination of IgM anti-AFP antibodies and AFP-IgM immune complexes / Gomiero, C; Pengo, Paolo; Gallotta, A; Biasiolo, A; Tono, N; Gatta, A; Pontisso, P; Matteucci, C; Fassina, G; Beneduce, L.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 54:S1(2011), pp. 382-382. ( Annual Meeting of the European Association for the Study of the Liver (EASL) Berlin March 30 - April 3, 2011).
Improved detection of HCC by co-determination of IgM anti-AFP antibodies and AFP-IgM immune complexes
Pengo, Paolo;
2011-01-01
Abstract
The detection of hepatocellular carcinoma (HCC) may be improved by analyzing the novel class of serumbiomarkers constituted by IgM immune complexes of well-known cancer antigens such as alpha-fetoprotein (AFP-IgM). To evaluate the relevance of the natural immune response to AFP for HCC diagnosis, we assessed the levels of IgM anti-AFP antibodies in serum samples of patients with HCC and with cirrhosis (CR) using a dedicated IgM anti-AFP assay. The assay result was compared to the diagnostic accuracy of the AFP-IgM test.Pubblicazioni consigliate
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