The detection of hepatocellular carcinoma (HCC) may be improved by analyzing the novel class of serumbiomarkers constituted by IgM immune complexes of well-known cancer antigens such as alpha-fetoprotein (AFP-IgM). To evaluate the relevance of the natural immune response to AFP for HCC diagnosis, we assessed the levels of IgM anti-AFP antibodies in serum samples of patients with HCC and with cirrhosis (CR) using a dedicated IgM anti-AFP assay. The assay result was compared to the diagnostic accuracy of the AFP-IgM test.
Improved detection of HCC by co-determination of IgM anti-AFP antibodies and AFP-IgM immune complexes
Pengo, Paolo;
2011-01-01
Abstract
The detection of hepatocellular carcinoma (HCC) may be improved by analyzing the novel class of serumbiomarkers constituted by IgM immune complexes of well-known cancer antigens such as alpha-fetoprotein (AFP-IgM). To evaluate the relevance of the natural immune response to AFP for HCC diagnosis, we assessed the levels of IgM anti-AFP antibodies in serum samples of patients with HCC and with cirrhosis (CR) using a dedicated IgM anti-AFP assay. The assay result was compared to the diagnostic accuracy of the AFP-IgM test.File in questo prodotto:
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