The risk of developing a CIN2+ lesion in women with HPV16 and 18, versus women with other HPV types: follow up study

Of the 12 known carcinogenic HPV types, HPV16 is by far the most carcinogenic in terms of numbers of cases of cervical cancer and its immediate precursor, cervical intraepithelial neoplasia grade 3 (CIN3). HPV18 is second in terms of etiologic importance (but is disproportionately important for adenocarcinomas)(1-3). Aims:Our study compares the risk of developing a CIN2+ lesions in women with HPV16 and 18, versus women with other HPV types. Sensitivity, specificity and their respective 95% confidence intervals (95%CI), positive predictive values (PPV) and negative predictive values (NPV) were also calculated on the basis of the results of cytologic and histologic follow-up.