When modeling the relationship between a response and some continuous covariates, assuming linearity may be too restrictive in many contexts. Naive solutions to overcome this limitation, such as categorisation of the predictor, have well-known drawbacks. A viable alternative is represented by spline functions. In epidemiological studies, the number and position of knots usually have an important meaning. Therefore, special attention should be posed to techniques that allow to choose the number and position of knots. The aim of the present work is to: 1. introduce a two-step Bayesian procedure within the semiparametric generalised linear model framework to be applied in epidemiological studies where the effect of a continuous exposure on risk is under investigation; 2. show how this framework is applied in a bivariate context where the aim is to modeling the joint effect of intensity and duration of alcohol drinking in cancer of the oral cavity.

Bivariate spline models to assess the joint effect of intensity and duration of alcohol drinking and cancer of the oral cavity: a focus on a novel approach

Di Credico Gioia;Pauli Francesco;Torelli Nicola;
2020-01-01

Abstract

When modeling the relationship between a response and some continuous covariates, assuming linearity may be too restrictive in many contexts. Naive solutions to overcome this limitation, such as categorisation of the predictor, have well-known drawbacks. A viable alternative is represented by spline functions. In epidemiological studies, the number and position of knots usually have an important meaning. Therefore, special attention should be posed to techniques that allow to choose the number and position of knots. The aim of the present work is to: 1. introduce a two-step Bayesian procedure within the semiparametric generalised linear model framework to be applied in epidemiological studies where the effect of a continuous exposure on risk is under investigation; 2. show how this framework is applied in a bivariate context where the aim is to modeling the joint effect of intensity and duration of alcohol drinking in cancer of the oral cavity.
978-88-943456-2-9
https://www.sismec.info/convegni/convegni-sismec/item/1046-atti-del-congresso-nazionale-2019
File in questo prodotto:
File Dimensione Formato  
ATTI_X_CONGRESSO_SISMEC.pdf

Accesso chiuso

Descrizione: contributo con frontespizio e indice
Tipologia: Documento in Versione Editoriale
Licenza: Digital Rights Management non definito
Dimensione 69.99 MB
Formato Adobe PDF
69.99 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/2972325
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact