This presentation introduced PermeaPad® as an in vitro tool for predicting biopharmaceutical drug performance, with emphasis on apparent permeability (Papp), high-throughput screening and advanced formulation testing. PermeaPad® applications for predicting intestinal absorption, investigating trans- and paracellular transport, and mimicking gastrointestinal conditions were presented. The use of the platform for enabling formulations, including liposomal systems and lipid-based formulations under lipolysis conditions, was also discussed, highlighting its potential for establishing meaningful in vitro–in vivo relationships.
In vitro tool for predicting biopharmaceutical drug performance / Di Cagno, M.P.. - (2022), pp. 1-28. (14th Annual Drug Discovery to Development Innovation Forum Leaders Inspire Action Berlin, Germany (remote presentaion due t Covid-19 outbreack) 24th-25th June).
In vitro tool for predicting biopharmaceutical drug performance
Massimiliano Pio di Cagno
2022-01-01
Abstract
This presentation introduced PermeaPad® as an in vitro tool for predicting biopharmaceutical drug performance, with emphasis on apparent permeability (Papp), high-throughput screening and advanced formulation testing. PermeaPad® applications for predicting intestinal absorption, investigating trans- and paracellular transport, and mimicking gastrointestinal conditions were presented. The use of the platform for enabling formulations, including liposomal systems and lipid-based formulations under lipolysis conditions, was also discussed, highlighting its potential for establishing meaningful in vitro–in vivo relationships.Pubblicazioni consigliate
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