| Nome |
# |
|
The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy, file e2913fdf-1661-f688-e053-3705fe0a67e0
|
295
|
|
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors, file e2913fda-6b67-f688-e053-3705fe0a67e0
|
238
|
|
Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2Aligand binding kinetics, file e2913fdb-dd53-f688-e053-3705fe0a67e0
|
210
|
|
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists, file e2913fda-bc50-f688-e053-3705fe0a67e0
|
190
|
|
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype, file e2913fdc-50d0-f688-e053-3705fe0a67e0
|
185
|
|
Chemical probes for the adenosine receptors, file e2913fdc-f231-f688-e053-3705fe0a67e0
|
177
|
|
Advances in Computational Techniques to Study GPCR-Ligand Recognition, file e2913fde-b222-f688-e053-3705fe0a67e0
|
143
|
|
Design, synthesis and evaluation of new indolylpyrimidylpiperazines for gastrointestinal cancer therapy, file e2913fdd-2104-f688-e053-3705fe0a67e0
|
141
|
|
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition, file e2913fdf-08ac-f688-e053-3705fe0a67e0
|
136
|
|
Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment, file e2913fdb-dd50-f688-e053-3705fe0a67e0
|
134
|
|
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives, file e2913fd9-c4a4-f688-e053-3705fe0a67e0
|
129
|
|
Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?, file e2913fdf-4a04-f688-e053-3705fe0a67e0
|
110
|
|
Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis, file e06576e6-8016-4daa-a2fa-b7e16c5d24a9
|
38
|
|
Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA, file e2913fdb-a970-f688-e053-3705fe0a67e0
|
35
|
|
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems, file e2913fdf-92e7-f688-e053-3705fe0a67e0
|
34
|
|
Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis, file 005ff35e-8adc-4f35-9657-3407aa13a763
|
26
|
|
Novel fluorescent hA3 adenosine receptor antagonists., file e2913fda-48e2-f688-e053-3705fe0a67e0
|
22
|
|
"Dual Anta-Inhibitors" of the A(2A) Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies, file 68882b75-5ffd-434f-9487-46b7ce17dcd0
|
20
|
|
The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?, file c7edb545-44b6-423f-9dec-5d0e8d852385
|
16
|
|
Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors, file 8aaa2bf1-2b9e-4234-8012-786e68db823e
|
10
|
|
A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ, file c7b02e59-ffe7-4841-b60c-c567ad6e91bb
|
10
|
|
[1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines, file 7a2dc764-c020-4292-989c-0211ed0d1410
|
8
|
|
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition, file e2913fde-f426-f688-e053-3705fe0a67e0
|
8
|
|
5-Alkylamino-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines. Influence of the Substituent on the Affinity at the Adenosine Receptor Subtypes, file e2913fda-49de-f688-e053-3705fe0a67e0
|
7
|
|
Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors, file 730e40d7-133e-450f-92bf-4d27ab031424
|
6
|
|
Advances in Computational Techniques to Study GPCR-Ligand Recognition, file e2913fdd-bb68-f688-e053-3705fe0a67e0
|
6
|
|
Therapeutic potential of A2 and A3 adenosine receptor: a review of novel patented ligands., file e2913fd9-c0a0-f688-e053-3705fe0a67e0
|
5
|
|
1,2,4]Triazolo[1,5-c]pyrimidines as New Potent Human A3 Adenosine Receptor Antagonists., file e2913fda-4f18-f688-e053-3705fe0a67e0
|
5
|
|
Adenine derivatives as inhibitors of the casein kinase CK1delta enzyme, file 68577b35-7816-4caf-8d11-6cfe18159a4a
|
4
|
|
A novel conjugated agent between dopamine and an A2A adenosine receptor antagonists as a potential anti-Parkinson multitarget approach., file e2913fd9-b93f-f688-e053-3705fe0a67e0
|
4
|
|
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists, file e2913fda-b770-f688-e053-3705fe0a67e0
|
4
|
|
The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy, file e2913fdd-5fbd-f688-e053-3705fe0a67e0
|
4
|
|
Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors, file c6bd6db6-7027-430f-9822-a3ef8d4d8485
|
3
|
|
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A2A Adenosine Receptor Antagonists, file e2913fd9-b8eb-f688-e053-3705fe0a67e0
|
3
|
|
N8-Isopentyl and N8-Phenylethyl Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists, file e2913fd9-bda7-f688-e053-3705fe0a67e0
|
3
|
|
The A3 adenosine receptor as multifaceted therapeutic Target: pharmacology, medicinal Chemistry, and In silico approaches, file e2913fd9-be51-f688-e053-3705fe0a67e0
|
3
|
|
Novel fluorescent antagonist as a molecular probe in A3 adenosine receptor binding assays using flow cytometry., file e2913fd9-c17d-f688-e053-3705fe0a67e0
|
3
|
|
Exploring the Directionality of 5-Substitutions in a New Series of 5-Alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a Strategy to Design Novel Human A3 Adenosine Receptor Antagonists., file e2913fd9-c41c-f688-e053-3705fe0a67e0
|
3
|
|
Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?, file e2913fdc-9497-f688-e053-3705fe0a67e0
|
3
|
|
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition, file e2913fdc-bbc9-f688-e053-3705fe0a67e0
|
3
|
|
Mixed-reversible and covalent kinase inhibition as a possible new strategy to treat neuro-inflammatory/degenerative diseases, file e2913fdd-02a9-f688-e053-3705fe0a67e0
|
3
|
|
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems, file e2913fde-76b3-f688-e053-3705fe0a67e0
|
3
|
|
Synthesis and biological evaluation of a new series of 1,2,4-Triazolo(1,5-a)-1,3,5-triazines as human A2A adenosine receptor antagonists with improved water solubility, file e2913fd9-0e68-f688-e053-3705fe0a67e0
|
2
|
|
N8-Isopentyl and N8-Phenylethyl Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists, file e2913fd9-bda8-f688-e053-3705fe0a67e0
|
2
|
|
N8-Isopentyl and N8-Phenylethyl Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists, file e2913fd9-bf0d-f688-e053-3705fe0a67e0
|
2
|
|
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5- c ]pyrimidines to explore the antagonist profiling on adenosine receptors: A preliminary structure-activity relationship study, file e2913fd9-c4f6-f688-e053-3705fe0a67e0
|
2
|
|
Anticonvulsivanti, file e2913fda-3d95-f688-e053-3705fe0a67e0
|
2
|
|
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors, file e2913fda-4f04-f688-e053-3705fe0a67e0
|
2
|
|
Chapter 1: A3 adenosine receptor ligands in the treatment of inflammation and cancer, file e2913fda-51d7-f688-e053-3705fe0a67e0
|
2
|
|
Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA, file e2913fdb-4a94-f688-e053-3705fe0a67e0
|
2
|
|
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition, file e2913fdc-bbca-f688-e053-3705fe0a67e0
|
2
|
|
Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor, file e2913fde-76aa-f688-e053-3705fe0a67e0
|
2
|
|
Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors, file f8758d1f-fcc9-4aaa-ace5-f9376c2698b7
|
2
|
|
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases, file 0445af8d-d790-4ac8-8a55-074e8983cf1a
|
1
|
|
[1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines, file 0632042b-fb6d-4c20-a450-c77261da55ab
|
1
|
|
Does the combination of optimal substitutions at the C(2)-, N(5)- and N(8)-positions of the pyrazolo-triazolo-pyrimidine scaffold guaranteee selective modulation of the human A(3) adenosine receptors?, file e2913fda-163d-f688-e053-3705fe0a67e0
|
1
|
|
[1,2,4]Triazolo[1,5-c]pyrimidine Nucleus as Adenosine Receptor Antagonists: Shift in Selectivity from A2A to A3 Adenosine Receptors., file e2913fda-4f8a-f688-e053-3705fe0a67e0
|
1
|
|
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype, file e2913fdc-8311-f688-e053-3705fe0a67e0
|
1
|
|
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example, file e2913fdc-88c2-f688-e053-3705fe0a67e0
|
1
|
|
Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes, file e2913fdd-0240-f688-e053-3705fe0a67e0
|
1
|
|
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors, file e2913fdd-0bcf-f688-e053-3705fe0a67e0
|
1
|
|
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 δinhibitors, file e2913fdd-4c28-f688-e053-3705fe0a67e0
|
1
|
| Totale |
2.421 |