ArTS Archivio della ricerca di Trieste

SPALLUTO, GIAMPIERO
 Distribuzione geografica
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Continente #
NA - Nord America 14.710
EU - Europa 6.683
AS - Asia 6.280
SA - Sud America 746
AF - Africa 192
OC - Oceania 22
Continente sconosciuto - Info sul continente non disponibili 19
Totale 28.652
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Nazione #
US - Stati Uniti d'America 14.510
SG - Singapore 2.263
CN - Cina 1.516
IT - Italia 1.248
SE - Svezia 1.220
UA - Ucraina 708
BR - Brasile 594
PL - Polonia 580
HK - Hong Kong 567
VN - Vietnam 529
FR - Francia 481
DE - Germania 452
KR - Corea 432
GB - Regno Unito 395
NL - Olanda 376
FI - Finlandia 344
TR - Turchia 310
RU - Federazione Russa 271
IN - India 194
IE - Irlanda 167
BG - Bulgaria 140
CA - Canada 98
BD - Bangladesh 71
JP - Giappone 69
CH - Svizzera 68
BE - Belgio 51
IQ - Iraq 50
AR - Argentina 46
MA - Marocco 44
AT - Austria 39
MX - Messico 38
ES - Italia 37
ID - Indonesia 37
PK - Pakistan 36
CZ - Repubblica Ceca 34
ZA - Sudafrica 27
EG - Egitto 25
EC - Ecuador 24
MY - Malesia 24
CI - Costa d'Avorio 23
SA - Arabia Saudita 23
UZ - Uzbekistan 23
VE - Venezuela 22
CO - Colombia 19
IL - Israele 18
AU - Australia 17
EU - Europa 17
LT - Lituania 15
CL - Cile 14
JM - Giamaica 14
AZ - Azerbaigian 13
KE - Kenya 13
PH - Filippine 13
PE - Perù 12
JO - Giordania 11
SN - Senegal 11
AE - Emirati Arabi Uniti 10
DZ - Algeria 10
BZ - Belize 9
IR - Iran 9
TT - Trinidad e Tobago 9
TW - Taiwan 9
TH - Thailandia 8
TN - Tunisia 8
BY - Bielorussia 7
NG - Nigeria 7
PY - Paraguay 7
TG - Togo 7
HN - Honduras 6
OM - Oman 6
CR - Costa Rica 5
HU - Ungheria 5
KZ - Kazakistan 5
NZ - Nuova Zelanda 5
PT - Portogallo 5
RO - Romania 5
RS - Serbia 5
SY - Repubblica araba siriana 5
UY - Uruguay 5
AL - Albania 4
BB - Barbados 4
DK - Danimarca 4
ET - Etiopia 4
KG - Kirghizistan 4
NP - Nepal 4
PA - Panama 4
PS - Palestinian Territory 4
BN - Brunei Darussalam 3
BO - Bolivia 3
EE - Estonia 3
GE - Georgia 3
GR - Grecia 3
LV - Lettonia 3
NO - Norvegia 3
PR - Porto Rico 3
SK - Slovacchia (Repubblica Slovacca) 3
SL - Sierra Leone 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BS - Bahamas 2
Totale 28.618
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Città #
Dallas 2.482
Singapore 1.365
Woodbridge 1.136
Fairfield 1.132
Houston 1.007
Ashburn 982
Ann Arbor 980
Chandler 665
Jacksonville 634
San Jose 615
Hefei 595
Wilmington 571
Hong Kong 542
Seattle 470
Warsaw 434
Seoul 419
Cambridge 396
Beijing 322
Trieste 319
Izmir 273
Princeton 257
Boardman 253
Amsterdam 232
Columbus 175
Chicago 174
The Dalles 169
Dublin 153
Ho Chi Minh City 142
Buffalo 140
Los Angeles 140
Lauterbourg 139
Sofia 139
Munich 133
Zgierz 131
Hanoi 124
Milan 118
Moscow 110
London 99
Santa Clara 92
Frankfurt am Main 82
Helsinki 81
New York 78
São Paulo 74
San Diego 70
Menlo Park 58
Mestre 58
Verona 53
Bern 50
North Bergen 50
Shanghai 46
Council Bluffs 44
Bremen 42
Düsseldorf 42
Tokyo 42
Brussels 41
Turku 41
West Jordan 41
Guangzhou 39
Rome 39
Dearborn 36
Da Nang 32
Phoenix 32
Toronto 31
Casablanca 28
Falls Church 27
Sacile 27
Vienna 27
Haiphong 26
Des Moines 25
Abidjan 23
Chennai 23
Brooklyn 22
Redwood City 22
Brno 21
Montreal 21
Orem 21
Dhaka 20
Nuremberg 20
Mumbai 18
Tashkent 18
Manchester 17
Rio de Janeiro 17
New Delhi 16
Norwalk 16
Pittsburgh 16
San Francisco 15
Baghdad 14
Zurich 14
Cairo 13
Fremont 13
Jakarta 13
Jinan 13
Nanjing 13
Padova 13
Bologna 12
Camerino 12
Codroipo 12
Nanchang 12
Philadelphia 12
Poplar 12
Totale 20.125
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Nome #
1,2,4-Triazolo[1,5-a]-1,3,5-triazine nucleus: a possible template for adenosine receptor subtypes. 851
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype 750
[1,2,4]Triazolo[1,5-a][1,3,5]Triazine Derivatives as Antagonists for the Adenosine Receptors: a Preliminary Study on Affinity at the A3 Subtype 691
1,2,4]Triazolo[1,5-c]pyrimidines as New Potent Human A3 Adenosine Receptor Antagonists. 671
[1,2,4]triazolo[1,5-c]pyrimidines as A(3) adenosine receptor antagonists 643
[1,2,4]Triazolo[1,5-c]pyrimidine Nucleus as Adenosine Receptor Antagonists: Shift in Selectivity from A2A to A3 Adenosine Receptors. 626
[1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines 612
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives 436
Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment 434
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 385
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists 341
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors 280
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5- c ]pyrimidines to explore the antagonist profiling on adenosine receptors: A preliminary structure-activity relationship study 275
A2Aadenosine receptor antagonists as therapeutic candidates: Are they still an interesting challenge? 275
ANTI-HIV PROPERTIES OF CATIONIC FULLERENE DERIVATIVES 272
Advances in Computational Techniques to Study GPCR-Ligand Recognition 265
. 6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors 252
null 245
Hemolytic Effects of Water-Soluble Fullerene Derivatives 242
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 δinhibitors 241
8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands 233
Chemical probes for the adenosine receptors 233
A new Multi-charged C60 Derivative: Synthesis and Biological Properties 227
N8-Isopentyl and N8-Phenylethyl Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine Derivatives as Adenosine Receptor Antagonists 226
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases 225
Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives. 225
Mixed-reversible and covalent kinase inhibition as a possible new strategy to treat neuro-inflammatory/degenerative diseases 225
Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors. 223
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems 219
CC-1065 and Duocarmycins: Recent Developments 218
Carbon nanotube substrates boost neuronal electrical signaling 218
A facile and novel synthesis of N2-, C6-substituted pyrazolo[3,4- d ]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists 218
null 217
Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View? 215
null 214
Structural investigations on a novel class of 1,2,4-triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. 212
7-Substituted-5-amino-2-(2-furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility 206
A novel conjugated agent between dopamine and an A2A adenosine receptor antagonists as a potential anti-Parkinson multitarget approach. 205
Chapter 1: A3 adenosine receptor ligands in the treatment of inflammation and cancer 205
Design, synthesis and evaluation of new indolylpyrimidylpiperazines for gastrointestinal cancer therapy 203
Synthesis and anti-HIV properties of new water-soluble bis-functionalized [60]fullerene derivatives 200
null 197
G protein-coupled receptors as challenging druggable targets: insights from in silico studies 196
Design, Synthesis and Biological Properties of Fulleropyrrolidine Derivatives as Potential DNA Photo-Probes 194
Synthesis of a Hybrid Fullerene-Trimethoxyindole-Oligonucleotide Conjugate 194
Synthesis, Biological properties and molecular modeling investigation of the first potent, selective and water soluble human A3 adenosine receptor antagonist 193
DNA-Photocleavage Agents 188
A facile and versatile route to the synthesis of fused 2-pyridones: Useful intermediates for policyclic systems 188
"Dual Anta-Inhibitors" of the A(2A) Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies 187
Synthesis, biological activity and molecular modeling investigation of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A3 adenosine receptor antagonists 183
PYRAZOLO TRIAZOLO PYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS: EFFECT OF THE N-5 BOND TYPE ON THE AFFINITY AND SELECTIVITY AT THE FOUR ADENOSINE RECEPTOR SUBTYPES 182
Discovery of simplified N2-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological evaluations and molecular docking studies 178
5-Alkylamino-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines. Influence of the Substituent on the Affinity at the Adenosine Receptor Subtypes 176
Adenosine Receptor Ligands, Probes, and Functional Conjugates: A 20-Year History of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidines (PTP) 176
A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ 174
Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: A possible template for adenosine receptor subtypes? 174
FLUORESCENT ANTAGONISTS OF THE A3 ADENOSINE RECEPTOR 174
Synthesis and Biological Studies of a New Series of 5-Heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists. Influence of the Heteroaryl Substituent on Binding Affinity and Molecular Modeling Investigations 173
Novel fluorescent hA3 adenosine receptor antagonists. 171
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example 171
Novel Versatile Fullerene Synthons 168
Biological Applications of Fullerene Derivatives: A Brief Overview 167
Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors 167
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A(3) and A(2B) adenosine receptor subtypes: A molecular modeling investigation 166
Ligand based-homology modeling as attractive tool to inspect GPCR structural plasticity 166
The A3 adenosine receptor as multifaceted therapeutic Target: pharmacology, medicinal Chemistry, and In silico approaches 165
Response surface analysis as alternative 3D-QSAR tool: human A3 adenosine receptor antagonists as a key study. 164
[3H]MRE 3008-F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors. 163
Rational Design, synthesis, and evaluation of a key analogues of CC-1065 and the duocarmycins. 163
Conjugable A3 Adenosine Receptor Antagonists: Probing the 5 Position of the Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine Scaffold. 163
Progress in the pursuit of therapeutic adenosine receptor antagonists 161
null 161
Potent and selective A2A adenosine receptor antagonists: Recent Improvements 160
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptor antagonists: new insights into structure affinity relathionship and receptor antagonist recognition. 160
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective 158
Synthesis and Molecular Modeling Studies of Fullerene-Trimethoxyindole-Oligonucleotide Conjugates as Possible Probes for Studying Photochemical Reactions in DNA Triple Helices 158
The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy 158
Synthesis and biological evaluation of a new series of 1,2,4-Triazolo(1,5-a)-1,3,5-triazines as human A2A adenosine receptor antagonists with improved water solubility 156
Fluorescent ligands for the A3 adenosine receptor. 155
New 2,6,9 tri-substituted adenines as adenosine receptor antagonists: a preliminary SAR profile. 154
null 154
Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA 154
Adenine derivatives as inhibitors of the casein kinase CK1delta enzyme 153
null 153
Anticonvulsivanti 153
Fullerene derivatives: an actractive tool for biological application 152
Fullerene derivatives: an attractive tool for biological application 152
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A2A Adenosine Receptor Antagonists. 151
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Highly Potent and Selective Human A3 Adenosine Receptor Antagonists: Influence of the Chain at the N8 pyrazole Nitrogen. 150
New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A1 adenosine receptor antagonists. 150
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells 149
Structural Investigations on a Novel Class of [1,2,4]Triazolo[1,5-c]pyrimidines as Adenosine Receptor Antagonists. 148
Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment 146
Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes 146
Fluorosulfonyl- and Bis-(b-Chloroethyl)amino-Phenylamino Functionalized Pyrazolo[4,3-e]1,2,4-Triazolo[1,5-c]Pyrimidine Derivatives: Irreversible Antagonists at the Human A3 Adenosine Receptor and Molecular Modeling Studies 140
Therapeutic potential of A2 and A3 adenosine receptor: a review of novel patented ligands. 140
null 140
Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling 138
Fluorescent ligands for adenosine receptors 138
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A2A Adenosine Receptor Antagonists 138
Totale 23.001
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Categoria #
all - tutte 74.120
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 74.120
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021516 0 0 0 0 0 0 0 0 0 209 97 210
2021/20221.767 121 148 76 390 23 101 66 59 176 216 88 303
2022/20232.252 203 268 162 303 224 438 6 202 288 31 91 36
2023/20241.486 113 109 82 127 113 94 210 337 5 72 107 117
2024/20253.522 115 122 387 298 269 305 187 186 438 414 270 531
2025/20269.689 838 1.299 2.487 677 523 642 1.082 274 912 955 0 0
Totale 29.157