The effectiveness of many drugs is extremely sensitive to their size and total surface area as these strongly affect their rate of dissolution in the body. Supercritical fluids are therefore used for improving these properties in drugs. In this work RESS technique is described for the micronization of two steroid drugs, progesterone and medroxyprogesterone acetate, from carbon dioxide supercritical solution. The first necessary step, to determine if the RESS technique is applicable, is the measurement of the drug solubility in the supercritical fluid and so the experimental procedure for this is included
Rapid Expansion of Supercritical Solutions Technology: Production of Fine Particles of Steroids Drugs
ALESSI, PAOLO;CORTESI, ANGELO;KIKIC, IRENEO;
2000-01-01
Abstract
The effectiveness of many drugs is extremely sensitive to their size and total surface area as these strongly affect their rate of dissolution in the body. Supercritical fluids are therefore used for improving these properties in drugs. In this work RESS technique is described for the micronization of two steroid drugs, progesterone and medroxyprogesterone acetate, from carbon dioxide supercritical solution. The first necessary step, to determine if the RESS technique is applicable, is the measurement of the drug solubility in the supercritical fluid and so the experimental procedure for this is includedFile in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
