Age –related cerebral degenerative changes are coupled therefore with decreased perfusion, usually assumed to be secondary to decreased cerebral metabolic demands (Meyer et al., 1999). During ageing declines in cerebral tissue densities in gray (polio-araiosis) and white matter (leuko-araiosis) reflect neuronal degenerative changes, which progress concurrent with cerebral perfusion declines. Rates of polio- and leuko-araiosis accelerate geometrically after age 60, correlating with cortical and subcortical atrophy and ventricular enlargement. In particular, leuko-araiosis correlates with advancing age, cerebral atrophy, hypoperfusion of white matter, and cognitive impairments (Meyer et al., 2000): what is surprising, is that leuko-araiosis is detectable in 9-19% of older “normal” subjects but is virtually always present in vascular dementia. Of special interest are the data emerging from the study of Meyer et al. (2000): normative subjects destined for later cognitive decline had excessive leuko-araiosis at study entry, suggesting leukoaraiosis is, itself, a risk factor for cognitive decline.We have studied the emerging role of hypotension in SVAD definition
Hypotension in subcortical vascular dementia,a new risk factor. Wasn’t it hypertension?
MORETTI, Rita;
2011-01-01
Abstract
Age –related cerebral degenerative changes are coupled therefore with decreased perfusion, usually assumed to be secondary to decreased cerebral metabolic demands (Meyer et al., 1999). During ageing declines in cerebral tissue densities in gray (polio-araiosis) and white matter (leuko-araiosis) reflect neuronal degenerative changes, which progress concurrent with cerebral perfusion declines. Rates of polio- and leuko-araiosis accelerate geometrically after age 60, correlating with cortical and subcortical atrophy and ventricular enlargement. In particular, leuko-araiosis correlates with advancing age, cerebral atrophy, hypoperfusion of white matter, and cognitive impairments (Meyer et al., 2000): what is surprising, is that leuko-araiosis is detectable in 9-19% of older “normal” subjects but is virtually always present in vascular dementia. Of special interest are the data emerging from the study of Meyer et al. (2000): normative subjects destined for later cognitive decline had excessive leuko-araiosis at study entry, suggesting leukoaraiosis is, itself, a risk factor for cognitive decline.We have studied the emerging role of hypotension in SVAD definitionPubblicazioni consigliate
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