The book summarises the findings and contributions of the European ARTEMIS project, CESAR, for improving and enabling interoperability of methods, tools, and processes to meet the demands in embedded systems development across four domains - avionics, automotive, automation and rail. The contributions give insight to an improved engineering and safety process life-cycle for the development of safety critical systems. They present new concept of engineering tools integration platform ( the so-called “Reference Technology Platform” or RTP) to improve the development of safety critical embedded systems. They also advance state-of-the-art in component-based development as well as component and system validation and verification, with tool support. In particular, the “Evaluation of CESAR: Pilot Applications” chapter describes industry relevant evaluated processes and in addition it illustrates power and flexibility of the proposed RTP framework for end-user instantiation to specific domain needs and processes.