Wernicke Korsakoff Encephalopathy

Consideration for Wernicke encephalopathy should be given to patients with any evidence of long-term alco- hol abuse or malnutrition and any of the following: acute confusion, decreased conscious level, ataxia, ophthalmo- plegia, memory disturbance, hypothermia with hypoten- sion, and delirium tremens. Wernicke encephalopathy should be considered when any patient with long-term malnutrition presents with confusion or altered metal sta- tus. Signi cant overlap exists between Wernicke enceph- alopathy and Korsako psychosis, in which patients ex- perience delayed and potentially irreversible anterograde and retrograde amnesia. For this reason, the two entities have been described together as Wernicke-Korsako syn- drome. Bariatric surgery, human immunode ciency virus, hyperemesis gravidarum, and other disorders associated with grossly impaired nutritional status have been asso- ciated with Wernicke-Korsako syndrome. Additionally, infantile thiamine de ciency with manifestations of Wer- nicke syndrome has been reported in infants fed formula that was de cient in thiamine. Implementation therapy, with thiamine is a fun- damental approach for the treatment of WE: it must be avoided the administration of ev glucose, which may cause a precipitation of thiamine defects. No therapy has been validated for the treatment of Korsako amnestic syndrome. erefore, the clinicians should avoid any po- tential precipitating factor in speci c patients, more at risk to develop Wernicke-Korsako syndrome.