GAM: Genomic Assemblies Merger. A Graph Based Method to Integrate Different Assemblies

Casagrande, Alberto; Cristian Del Fabbro,; Simone, Scalabrin; Alberto, Policriti

doi:10.1109/BIBM.2009.28

Many software tools are currently available to solve the hard goal of assembling millions of fragments produced in sequencing projects. Such a variety includes packages for long and short reads, generated by classical and next- generation sequencing technologies. Often the result produced by different tools can diverge—sometime significantly—for many reasons: the underlying algorithm, the data structures employed, the heuristics implemented, default parameters, etc. On the ground of the above considerations, we were motivated in developing a methodology which may both guide in a comparison of different assembler’s output and improve the overall quality of the genome assembly sequences, by merging the sequences produced by different assembly programs.

Titolo:	GAM: Genomic Assemblies Merger. A Graph Based Method to Integrate Different Assemblies
Autori:	CASAGRANDE, ALBERTO CRISTIAN DEL FABBRO SIMONE SCALABRIN ALBERTO POLICRITI mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2009
Abstract:	Many software tools are currently available to solve the hard goal of assembling millions of fragments produced in sequencing projects. Such a variety includes packages for long and short reads, generated by classical and next- generation sequencing technologies. Often the result produced by different tools can diverge—sometime significantly—for many reasons: the underlying algorithm, the data structures employed, the heuristics implemented, default parameters, etc. On the ground of the above considerations, we were motivated in developing a methodology which may both guide in a comparison of different assembler’s output and improve the overall quality of the genome assembly sequences, by merging the sequences produced by different assembly programs.
Handle:	http://hdl.handle.net/11368/2952
ISBN:	9780769538853
Appare nelle tipologie:	4.1 Contributo in Atti Convegno (Proceeding)

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