Many software tools are currently available to solve the hard goal of assembling millions of fragments produced in sequencing projects. Such a variety includes packages for long and short reads, generated by classical and next- generation sequencing technologies. Often the result produced by different tools can diverge—sometime significantly—for many reasons: the underlying algorithm, the data structures employed, the heuristics implemented, default parameters, etc. On the ground of the above considerations, we were motivated in developing a methodology which may both guide in a comparison of different assembler’s output and improve the overall quality of the genome assembly sequences, by merging the sequences produced by different assembly programs.
Titolo: | GAM: Genomic Assemblies Merger. A Graph Based Method to Integrate Different Assemblies |
Autori: | |
Data di pubblicazione: | 2009 |
Abstract: | Many software tools are currently available to solve the hard goal of assembling millions of fragments produced in sequencing projects. Such a variety includes packages for long and short reads, generated by classical and next- generation sequencing technologies. Often the result produced by different tools can diverge—sometime significantly—for many reasons: the underlying algorithm, the data structures employed, the heuristics implemented, default parameters, etc. On the ground of the above considerations, we were motivated in developing a methodology which may both guide in a comparison of different assembler’s output and improve the overall quality of the genome assembly sequences, by merging the sequences produced by different assembly programs. |
Handle: | http://hdl.handle.net/11368/2952 |
ISBN: | 9780769538853 |
Appare nelle tipologie: | 4.1 Contributo in Atti Convegno (Proceeding) |