Bioreduction of PEG-acetoacetate 1 is achieved using dry baker's yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)-3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.

Baker's yeast reduction of PEG-linked acetoacetate

BONORA, GIAN MARIA;DRIOLI, Sara;FORZATO, Cristina;NITTI, PATRIZIA;PITACCO, GIULIANA
2005

Abstract

Bioreduction of PEG-acetoacetate 1 is achieved using dry baker's yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)-3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/1690215
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