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SARS-CoV-2-induced damage to rat cortical neuronal networks ex vivo is mediated by the pro-inflammatory activation of the cGAS-STING pathway

Severe Acute Respiratory Syndrome Coronavirus-2 infection has been associated to neurological symptoms characteristic of long-lasting post-acute coronavirus disease. However, the complex mechanisms involved in these clinical manifestations are still unclear. Glial cells are key to inflammation and neurodegeneration in response to central nervous system infection. To investigate this pathway, induced pluripotent stem cells human astrocytes and human microglial HMC3 cells were infected with SAR...

Produzione sistemico relazionale della fiducia e delle certezze (nota a Cons. Stato, sez. VII, 10 giugno 2025, n. 5020)

La certezza giuridica costituisce una delle funzioni essenziali dell’ordinamento amministrativo. Essa è volta a garantire la stabilità e la sicurezza dei rapporti giuridici, economici e sociali, attraverso la conoscenza di fatti, stati e qualità che il diritto qualifica come veri. In questa logica, i principi di autocertificazione e decertificazione rappresentano il tentativo di tradurre la certezza da valore statico a meccanismo dinamico di cooperazione tra cittadino e amministrazione. Nel ...

Bilirubin Triggers Calcium Elevations and Dysregulates Giant Depolarizing Potentials During Rat Hippocampus Maturation

Neonatal hyperbilirubinemia may result in long-lasting motor, auditory and learning impairments. The mechanisms responsible for the localization of unconjugated bilirubin (UCB) to specific brain areas as well as those involved in potentially permanent central nervous system (CNS) dysfunctions are far from being clear. One area of investigation includes exploring how hyperbilirubinemia determines neuronal alterations predisposing to neurodevelopmental disorders. We focused on the hippocampus a...

TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in Drosophila and Human ALS Models

The pathological loss of nuclear TDP-43 is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to extensive alterations in RNA metabolism and a broad number of neuronal transcripts. However, the key effectors linking TDP-43 dysfunction to synaptic defects remain unclear. In this study, using Drosophila and human iPSC-derived motoneurons, we identify Rab4 as a direct and conserved target of TDP-43, whose expression is necessary and sufficient to recover...

Combined Climate and Chemical Stressors: How Spatial Variability Shapes the Response of Ficopomatus enigmaticus (Fauvel, 1923) to Dimethyl Sulfoxide (DMSO) and Heatwaves, and What It Means for Ecotoxicology

Ficopomatus enigmaticus, a reef-forming serpulid, has emerged as a promising candidate for biomonitoring and ecotoxicology studies. Recent research has focused on adult stress responses, highlighting the need to understand population-specific responses. This study employed a multi-biomarker approach to investigate how F. enigmaticus adults from two populations in the NE Adriatic (Site A) and NE Tyrrhenian (Site B) responded to chronic exposure to heat and chemical stress (dimethyl sulfoxide,...

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