1 Contributo in Rivista(Articolo Rivista)

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1.1 Articolo in Rivista 64497
1.2 Recensione in Rivista 1294
1.3 Scheda bibliografica 99
1.4 Nota a sentenza 582
1.5 Abstract in Rivista 1591
1.6 Traduzione in Rivista 106
1.7 Contributo in atti di convegno pubblicato su rivista 29

Prodotti recenti

Missing Value Replacement in Strings and Applications

Missing values arise routinely in real-world sequential (string) datasets due to: (1) imprecise data measurements; (2) flexible sequence modeling, such as binding profiles of molecular sequences; or (3) the existence of confidential information in a dataset which has been deleted deliberately for privacy protection. In order to analyze such datasets, it is often important to replace each missing value, with one or more valid letters, in an efficient and effective way. Here we formalize this t...

Decomposition results for functions with bounded variation

Some decomposition results for functions with bounded variation are obtained by using Gagliardo's Theorem on the surjectivity of the trace operator from W1,1(Ω) into L1(∂Ω). More precisely, we prove that every BV function can be written as the sum of a BV function without jumps and a BV function without Cantor part. Alternatively, it can be written as the sum of a BV function without jumps and a purely ingular BV function (i.e., a function whose gradient is singular with respect to the Lebesg...

Model decomposition and stochastic fragments

In this paper, we discuss a method for decomposition, abstraction and reconstruction of the stochastic semantics of rule-based systems with conserved number of agents. Abstraction is induced by counting fragments instead of the species, which are the standard entities of information in molecular signaling. The rule-set can be decomposed to smaller rule-sets, so that the fragment-based dynamics of the whole rule-set is exactly a composition of species-based dynamics of smaller rule-sets. The r...

Transcriptional Phenocopies of Deleterious KEAP1 Mutations Correlate with Survival Outcomes in Lung Cancer Treated with Immunotherapy

Co-occurring mutations in KEAP1 and STK11/KRAS have emerged as determinants of survival outcomes in patients with non–small cell lung cancer (NSCLC) treated with immunotherapy. However, these mutational contexts identify a fraction of nonresponders to immune checkpoint inhibitors. We hypothesized that KEAP1 wild-type tumors recapitulate the transcriptional footprint of KEAP1 mutations and that this KEAPness phenotype can determine immune responsiveness with higher precision compared to mutati...

Integrated transcriptomic and histological insights into immune and stress-related pathways in the Antarctic sea anemone Urticinopsis antarctica

Antarctic sea anemones are dominant benthic predators, yet their molecular adaptive strategies to polar environments remain poorly understood. Urticinopsis antarctica is one of the most abundant Antarctic actiniarians, but until now it has lacked any integrated molecular characterisation This study provides the first comprehensive analysis combining de novo transcriptomics with histological and cytological observations to investigate immune and stress-response mechanisms in this azooxanthella...

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