The early identification of a neurological involvement in Gaucher’s Disease (GD) is essential for a correct dosage of the enzymatic therapy. The saccadic eye movement characteristics of 15 patients affected by the non-neurological GD form shown normal peak velocity values and some slight alterations of the velocity profiles, present in more than 70% of the recorded eye movements in four cases, two of them later developed an epilepsy. This fact support the hypothesis that the presence of alterations in the velocity profile of the most part of saccadic movements is an index of initial neurological involvement; further evaluations are necessary in order to understand if an increase of therapy dose should be used in all the subjects presenting such saccadic alterations.

Saccadic analysis for early identification of neurological involvement in Gaucher’s disease

ACCARDO, AGOSTINO;
2005-01-01

Abstract

The early identification of a neurological involvement in Gaucher’s Disease (GD) is essential for a correct dosage of the enzymatic therapy. The saccadic eye movement characteristics of 15 patients affected by the non-neurological GD form shown normal peak velocity values and some slight alterations of the velocity profiles, present in more than 70% of the recorded eye movements in four cases, two of them later developed an epilepsy. This fact support the hypothesis that the presence of alterations in the velocity profile of the most part of saccadic movements is an index of initial neurological involvement; further evaluations are necessary in order to understand if an increase of therapy dose should be used in all the subjects presenting such saccadic alterations.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/1691333
 Avviso

Registrazione in corso di verifica.
La registrazione di questo prodotto non è ancora stata validata in ArTS.

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 10
social impact