Patients and Methods. A total of 213 naive patients with chronic hepatitis C were treated with 4 different schedules of human leucocyte interferon alpha. Sustained response was defined as persistently normal alanine amino transferase values with negative serum hepatitis C virus-RNA up to 12 months after therapy withdrawal. Results. Rates of sustained response were 16% with 3 MU tiw for 6 months, 33% with 6 MU tiw for 5 months after a priming dose of 9 MU tiw for a month, 32% with 3 MU tiw for 12 months and 20% with 3 MU daily for 6 months. The major factors affecting the response rate were age and the hepatitis C Virus genotype, as a sustained response was significantly higher in patients under 45 years and infected by hepatitis 6 virus types other than hepatitis C virus-1. Treatment was well tolerated and side-effects and drop-out events were similar to those described with other types of alpha -interferons.



Titolo: Human leucocyte interferon-alpha in the treatment of chronic hepatitis C
Autori: 
CROCE', Saveria
TIRIBELLI, CLAUDIO
POZZATO, GABRIELE
mostra contributor esterni 
Data di pubblicazione: 2001
Rivista: 
DIGESTIVE AND LIVER DISEASE  
Abstract: Patients and Methods. A total of 213 naive patients with chronic hepatitis C were treated with 4 different schedules of human leucocyte interferon alpha. Sustained response was defined as persistently normal alanine amino transferase values with negative serum hepatitis C virus-RNA up to 12 months after therapy withdrawal. Results. Rates of sustained response were 16% with 3 MU tiw for 6 months, 33% with 6 MU tiw for 5 months after a priming dose of 9 MU tiw for a month, 32% with 3 MU tiw for 12 months and 20% with 3 MU daily for 6 months. The major factors affecting the response rate were age and the hepatitis C Virus genotype, as a sustained response was significantly higher in patients under 45 years and infected by hepatitis 6 virus types other than hepatitis C virus-1. Treatment was well tolerated and side-effects and drop-out events were similar to those described with other types of alpha -interferons.
Handle: http://hdl.handle.net/11368/1691973
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1590-8658(01)80090-6
Appare nelle tipologie:1.1 Articolo in Rivista

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