Asymmetrical twin cantilevers for single molecule detection

Recently, there has been growing interest in sensors based on frequency shift detection of mechanical resonators, that has led to extremely sensitive diagnostic methods for medicine and biology. Here the authors propose and demonstrate a strategy capable of detecting the presence of a few macromolecules, which uses an asymmetrical cantilever structure of several microns in size, operated at room temperature, and under ordinary vacuum conditions. The idea is to detect the presence of one or more molecules by detecting the mechanical cross-talk induced by the molecular link between a short cantilever and an array of longer cantilevers facing the short one.