Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital

Lagatolla, Cristina; Tonin, Enrico Angelo; Monti Bragadin, C; Dolzani, Lucilla; Gombac, F; Bearzi, C; Edalucci, E; Gionechetti, Fabrizia; Rossolini, Gm

doi:10.3201/eid1003.020799

Acquired metallo-β-lactamases (MBLs) can confer broad-spectrum β-lactam resistance (including carbapenems) not reversible by conventional β-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying blaVIM MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either blaVIM-1-like or blaVIM-2-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.

Titolo:	Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital
Autori:	LAGATOLLA, CRISTINA TONIN, ENRICO ANGELO MONTI BRAGADIN C DOLZANI, LUCILLA GOMBAC F BEARZI C EDALUCCI E GIONECHETTI, FABRIZIA ROSSOLINI GM mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2004
Rivista:	EMERGING INFECTIOUS DISEASES
Abstract:	Acquired metallo-β-lactamases (MBLs) can confer broad-spectrum β-lactam resistance (including carbapenems) not reversible by conventional β-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying blaVIM MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either blaVIM-1-like or blaVIM-2-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.
Handle:	http://hdl.handle.net/11368/1693293
Digital Object Identifier (DOI):	http://dx.doi.org/10.3201/eid1003.020799
Appare nelle tipologie:	1.1 Articolo in Rivista

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