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EnglishAbstract—A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.
| Titolo: | Synthesis and anti-HIV properties of new water-soluble bis-functionalized [60]fullerene derivatives |
| Autori: | |
| Data di pubblicazione: | 2003 |
| Rivista: | |
| Abstract: | Abstract—A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility. |
| Handle: | http://hdl.handle.net/11368/1693534 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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