ArTS Archivio della ricerca di Trieste
ArTS è il sistema di gestione integrata dei dati della ricerca adottato dall' Università degli Studi di Trieste
EnglishAbstract—A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11368/1693534| Titolo: | Synthesis and anti-HIV properties of new water-soluble bis-functionalized [60]fullerene derivatives |
| Autori interni: | DA ROS, TATIANA SPALLUTO, GIAMPIERO PRATO, MAURIZIO BOSI, Susanna |
| Data di pubblicazione: | 2003 |
| Rivista: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Abstract: | Abstract—A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility. |
| Handle: | http://hdl.handle.net/11368/1693534 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.