Abstract—A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.
Synthesis and anti-HIV properties of new water-soluble bis-functionalized [60]fullerene derivatives
BOSI, Susanna;DA ROS, TATIANA;SPALLUTO, GIAMPIERO;PRATO, MAURIZIO
2003-01-01
Abstract
Abstract—A new series of bis-functionalized fullerene C60 derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C60 nucleus has been investigated, indicating that only trans-2isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.File in questo prodotto:
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