In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.

Fattorini, L; Gennaro, Renato; Zanetti, M; Tan, D; Brunori, L; Giannoni, F; Pardini, M; Orefici, G.

doi:10.1016/j.peptides.2004.04.003

The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.

Titolo:	In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.
Autori:	FATTORINI L GENNARO, RENATO ZANETTI M TAN D BRUNORI L GIANNONI F PARDINI M OREFICI G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2004
Rivista:	PEPTIDES
Abstract:	The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.
Handle:	http://hdl.handle.net/11368/1694890
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.peptides.2004.04.003
URL:	http://www.sciencedirect.com/science/article/pii/S0196978104001573
Appare nelle tipologie:	1.1 Articolo in Rivista

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