NAMI-A, i. e. (imH)[trans-RuCl 4 (dmso-S)(im)] (im = imidazole, dmso = dimethylsulfoxide), is a Ru(III) complex that, after extensive preclinical investigations that evidenced its remarkable and specific activity against metastases, has recently and successfully completed a Phase I trial (first ruthenium complex ever to reach clinical testing). This review article, after a brief summary of the main chemical and pharmacological aspects of NAMI-A, focuses on the development of new classes of ruthenium complexes originated from the NAMI-A frame.



Titolo: Ruthenium antimetastatic agents
Autori: 
ALESSIO, ENZO
BERGAMO, ALBERTA
SAVA, GIANNI
mostra contributor esterni 
Data di pubblicazione: 2004
Rivista: 
CURRENT TOPICS IN MEDICINAL CHEMISTRY  
Abstract: NAMI-A, i. e. (imH)[trans-RuCl 4 (dmso-S)(im)] (im = imidazole, dmso = dimethylsulfoxide), is a Ru(III) complex that, after extensive preclinical investigations that evidenced its remarkable and specific activity against metastases, has recently and successfully completed a Phase I trial (first ruthenium complex ever to reach clinical testing). This review article, after a brief summary of the main chemical and pharmacological aspects of NAMI-A, focuses on the development of new classes of ruthenium complexes originated from the NAMI-A frame.
Handle: http://hdl.handle.net/11368/1696167
Digital Object Identifier (DOI): http://dx.doi.org/10.2174/1568026043387421
Appare nelle tipologie:1.1 Articolo in Rivista

File in questo prodotto:
Non ci sono file associati a questo prodotto.
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11368/1696167
  • Citazioni
  • ND

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
 
 
 
©2014 University of Trieste dove siamo Privacy
Piazzale Europa,1 34127 Trieste, Italia - Tel. +39 040.558.7111 - P.IVA 00211830328 - C.F. 80013890324 - P.E.C.: ateneo@pec.units.it
 Copyright © 2020