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EnglishNAMI-A, i. e. (imH)[trans-RuCl 4 (dmso-S)(im)] (im = imidazole, dmso = dimethylsulfoxide), is a Ru(III) complex that, after extensive preclinical investigations that evidenced its remarkable and specific activity against metastases, has recently and successfully completed a Phase I trial (first ruthenium complex ever to reach clinical testing). This review article, after a brief summary of the main chemical and pharmacological aspects of NAMI-A, focuses on the development of new classes of ruthenium complexes originated from the NAMI-A frame.
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http://hdl.handle.net/11368/1696167| Titolo: | Ruthenium antimetastatic agents |
| Autori interni: | ALESSIO, ENZO SAVA, GIANNI |
| Data di pubblicazione: | 2004 |
| Rivista: | CURRENT TOPICS IN MEDICINAL CHEMISTRY |
| Abstract: | NAMI-A, i. e. (imH)[trans-RuCl 4 (dmso-S)(im)] (im = imidazole, dmso = dimethylsulfoxide), is a Ru(III) complex that, after extensive preclinical investigations that evidenced its remarkable and specific activity against metastases, has recently and successfully completed a Phase I trial (first ruthenium complex ever to reach clinical testing). This review article, after a brief summary of the main chemical and pharmacological aspects of NAMI-A, focuses on the development of new classes of ruthenium complexes originated from the NAMI-A frame. |
| Handle: | http://hdl.handle.net/11368/1696167 |
| Digital Object Identifier (DOI): | 10.2174/1568026043387421 |
| Appare nelle tipologie: | 1.1 Articolo in Rivista |
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