We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.
TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION / Thuault, S; Valcourt, U; Petersen, M; Manfioletti, Guidalberto; Heldin, Ch; Moustakas, A.. - In: THE JOURNAL OF CELL BIOLOGY. - ISSN 0021-9525. - STAMPA. - 174:(2006), pp. 175-183. [10.1083/jcb.200512110]
TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION.
MANFIOLETTI, GUIDALBERTO;
2006-01-01
Abstract
We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.Pubblicazioni consigliate
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