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    • We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.


    Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11368/1696755

    Titolo: TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION.
    Autori interni: MANFIOLETTI, GUIDALBERTO
    Data di pubblicazione: 2006
    Rivista: THE JOURNAL OF CELL BIOLOGY  
    Abstract: We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.
    Handle: http://hdl.handle.net/11368/1696755
    Digital Object Identifier (DOI): 10.1083/jcb.200512110
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