We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.

TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION.

MANFIOLETTI, GUIDALBERTO;
2006

Abstract

We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11368/1696755
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