TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION.

We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.



Titolo: TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION.
Autori: 
MANFIOLETTI, GUIDALBERTO
mostra contributor esterni 
Data di pubblicazione: 2006
Rivista: 
THE JOURNAL OF CELL BIOLOGY  
Abstract: We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.
Handle: http://hdl.handle.net/11368/1696755
Digital Object Identifier (DOI): http://dx.doi.org/10.1083/jcb.200512110
Appare nelle tipologie:1.1 Articolo in Rivista

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