We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients.
Titolo: | TRANSFORMING GROWTH FACTOR-{BETA} EMPLOYS HMGA2 TO ELICIT EPITHELIAL-MESENCHYMAL TRANSITION. | |
Autori: | ||
Data di pubblicazione: | 2006 | |
Rivista: | ||
Abstract: | We delineate a pathway that links TGF-beta signaling to the control of epithelial differentiation via HMGA2 and a cohort of major regulators of tumor invasiveness and metastasis. This network of signaling/transcription factors that work sequentially to establish EMT suggests that combinatorial detection of these proteins could serve as a new tool for EMT analysis in cancer patients. | |
Handle: | http://hdl.handle.net/11368/1696755 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1083/jcb.200512110 | |
Appare nelle tipologie: | 1.1 Articolo in Rivista |
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