Enantioselective deacetylation of a-(±)-botryodiplodin acetate was successfully accomplished by means of lipase PS to afford (+)-botryodiplodin and a-(+)-botryodiplodin acetate with high enantiomeric excesses. Enzyme-mediated transesterification of the acetylated molecule with n-butanol, as well as its hydrolysis in several organic solvents, are also reported. The CD spectra of (+)-botryodiplodin and a-(+)-botryodiplodin acetate are also presented.
Lipase-catalyzed deacetylation of botryodiplodin acetate / Forzato, Cristina; G., Furlan; F., Ghelfi; Nitti, Patrizia; Pitacco, Giuliana; F., Roncaglia; Valentin, Ennio. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 18:(2007), pp. 447-450. [10.1016/j.tetasy.2007.02.008]
Lipase-catalyzed deacetylation of botryodiplodin acetate
FORZATO, Cristina;NITTI, PATRIZIA;PITACCO, GIULIANA;VALENTIN, ENNIO
2007-01-01
Abstract
Enantioselective deacetylation of a-(±)-botryodiplodin acetate was successfully accomplished by means of lipase PS to afford (+)-botryodiplodin and a-(+)-botryodiplodin acetate with high enantiomeric excesses. Enzyme-mediated transesterification of the acetylated molecule with n-butanol, as well as its hydrolysis in several organic solvents, are also reported. The CD spectra of (+)-botryodiplodin and a-(+)-botryodiplodin acetate are also presented.Pubblicazioni consigliate
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