Enantiopure (99% ee) cis- and trans-gamma-benzylparaconic acids and their ethyl esters were synthesized by a procedure involving kinetic enzymatic resolution of the corresponding lactonic esters with alfa-chymotrypsin (a-CT) with acetone added as a cosolvent. Their absolute configurations were determined by 1H NMR analysis of their 1-(9-anthryl)-2,2,2-trifluoroethyl esters.
Chemoenzymatic synthesis of diastereomeric ethyl g-benzyl paraconates and determination of the absolute configurations of their acids / Berti, Federico; Felluga, Fulvia; Forzato, Cristina; G., Furlan; Nitti, Patrizia; Pitacco, Giuliana; Valentin, Ennio. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 17:(2006), pp. 2344-2353. [10.1016/j.tetasy.2006.08.013]
Chemoenzymatic synthesis of diastereomeric ethyl g-benzyl paraconates and determination of the absolute configurations of their acids
BERTI, FEDERICO;FELLUGA, FULVIA;FORZATO, Cristina;NITTI, PATRIZIA;PITACCO, GIULIANA;VALENTIN, ENNIO
2006-01-01
Abstract
Enantiopure (99% ee) cis- and trans-gamma-benzylparaconic acids and their ethyl esters were synthesized by a procedure involving kinetic enzymatic resolution of the corresponding lactonic esters with alfa-chymotrypsin (a-CT) with acetone added as a cosolvent. Their absolute configurations were determined by 1H NMR analysis of their 1-(9-anthryl)-2,2,2-trifluoroethyl esters.Pubblicazioni consigliate
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