The expression of TRAIL and TRAIL receptors was investigated in resting and cytokine-activated purified primary human NK and CD8(+) T cells. We found out that once activated the major cytotoxic effector cells are potentially sensitive to TRAIL but are physiologically protected from its apoptotic action by intracellular level of c-FLIP.
Activated human NK and CD8+ T cells express both TNF-related apoptosis inducing ligand (TRAIL) and TRAIL receptors, but are resistant to TRAIL-mediated cytotoxicity.
PONTI, CRISTINA;
2004-01-01
Abstract
The expression of TRAIL and TRAIL receptors was investigated in resting and cytokine-activated purified primary human NK and CD8(+) T cells. We found out that once activated the major cytotoxic effector cells are potentially sensitive to TRAIL but are physiologically protected from its apoptotic action by intracellular level of c-FLIP.File in questo prodotto:
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