In this study, we showed the existence of a positive correlation between the amount of HIV-1 RNAin HIV-1 seropositive subjects and the plasma levels of TRAIL and investigated the effect of Tat on the expression/activity of both apical caspase-8 and -10 and c-FLIP. Taken together, these results provide a molecular basis to explain the resistance of tat-expressing Jurkat cells to apoptosis induced by TRAIL and, possibly, to other death-inducing ligands.
HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity / Gibellini, D; CARLA RE, M; Ponti, Cristina; Vitone, F; Bon, I; Fabbri, G; DI IASIO, Mg; Zauli, G.. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - STAMPA. - 203:(2005), pp. 547-556. [10.1002/jcp.20252]
HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity.
PONTI, CRISTINA;
2005-01-01
Abstract
In this study, we showed the existence of a positive correlation between the amount of HIV-1 RNAin HIV-1 seropositive subjects and the plasma levels of TRAIL and investigated the effect of Tat on the expression/activity of both apical caspase-8 and -10 and c-FLIP. Taken together, these results provide a molecular basis to explain the resistance of tat-expressing Jurkat cells to apoptosis induced by TRAIL and, possibly, to other death-inducing ligands.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
