The synthesis of novel functionalized fullerene derivatives is reported: a DNA minor groove binder such as trimethoxyindole- 2-carboxylate (TMI) and an oligonucleotide chain have been covalently linked to C60 with the aim of duplicating DNA interactions for increasing sequence selectivity.
Synthesis of a Hybrid Fullerene-Trimethoxyindole-Oligonucleotide Conjugate
DA ROS, TATIANA;SPALLUTO, GIAMPIERO;PRATO, MAURIZIO
2001-01-01
Abstract
The synthesis of novel functionalized fullerene derivatives is reported: a DNA minor groove binder such as trimethoxyindole- 2-carboxylate (TMI) and an oligonucleotide chain have been covalently linked to C60 with the aim of duplicating DNA interactions for increasing sequence selectivity.File in questo prodotto:
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