A fullerene derivative containing a free amino group has been condensed with N-Fmoc-L-glutamic acid r-tert-butyl ester to give a C60-functionalized amino acid. The carboxylic end of this amino acid has been deprotected in acidic conditions, and the resulting acid has been used for solid-phase peptide synthesis. The final peptide, cleaved from the resin, was very soluble in water solutions and showed antimicrobial activity against two representative bacteria
A Novel [60]Fullerene Amino Acid for Use in Solid Phase Peptide Synthesis
DA ROS, TATIANA;TOSSI, ALESSANDRO;PRATO, MAURIZIO
2001-01-01
Abstract
A fullerene derivative containing a free amino group has been condensed with N-Fmoc-L-glutamic acid r-tert-butyl ester to give a C60-functionalized amino acid. The carboxylic end of this amino acid has been deprotected in acidic conditions, and the resulting acid has been used for solid-phase peptide synthesis. The final peptide, cleaved from the resin, was very soluble in water solutions and showed antimicrobial activity against two representative bacteriaFile in questo prodotto:
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