A series of water-soluble fullerene C60 derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. It was observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.
Hemolytic Effects of Water-Soluble Fullerene Derivatives / Bosi, S., Feruglio, L., DA ROS, T., Spalluto, G., Gregoretti, B., Terdoslavich, M., Decorti, G., Passamonti, S., Moro, S., Prato, M.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 47:(2004), pp. 6711-6715. [10.1021/jm0497489]
Hemolytic Effects of Water-Soluble Fullerene Derivatives
BOSI, Susanna;DA ROS, TATIANA;SPALLUTO, GIAMPIERO;DECORTI, GIULIANA;PASSAMONTI, SABINA;PRATO, MAURIZIO
2004-01-01
Abstract
A series of water-soluble fullerene C60 derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. It was observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.Pubblicazioni consigliate
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