The role of adenosine A3 receptor activation during ischaemia-like conditions produced byoxy gen and glucose deprivation (OGD) was evaluated with extracellular recordings from the CA1 region of rat hippocampal slices. In all, 7 min of OGD evoked tissue anoxic depolarisation (AD, peak atB7 min from OGD start, n¼20) and were invariablyfollowed byirreversible loss of electrically evoked field epsps (fepsps, n¼42).
A3 Adenosine receptor antagonistsdelay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro / Pugliese, Am; Coppi, E; Spalluto, Giampiero; Corradetti, R; Pedata, F.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 147:(2006), pp. 524-532.
A3 Adenosine receptor antagonistsdelay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro
SPALLUTO, GIAMPIERO;
2006-01-01
Abstract
The role of adenosine A3 receptor activation during ischaemia-like conditions produced byoxy gen and glucose deprivation (OGD) was evaluated with extracellular recordings from the CA1 region of rat hippocampal slices. In all, 7 min of OGD evoked tissue anoxic depolarisation (AD, peak atB7 min from OGD start, n¼20) and were invariablyfollowed byirreversible loss of electrically evoked field epsps (fepsps, n¼42).Pubblicazioni consigliate
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